{"created":"2023-06-20T16:49:18.106713+00:00","id":21491,"links":{},"metadata":{"_buckets":{"deposit":"70bc6ee2-3242-4261-8dbc-060efa0c6a8d"},"_deposit":{"created_by":3,"id":"21491","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"21491"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00021491","sets":["14:2667:4613"]},"author_link":["31960","3914","3374"],"control_number":"21491","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2019)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09141/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：FORMENコホートの10年次追跡調査と縦断解析を実施し、ベースライン時のオステオカルシン(OC)と低カルボキシル化OC(ucOC)の低値とベースライン時の糖尿病とメタボリック症候群の有病オッズ比の高値との有意な関連は見られたが、追跡期間中の新規発症オッズ比との有意な関連は見られなかった。これより、OC、ucOCの低値が糖尿病やメタボリック症候群を惹起するのではなく、インスリン抵抗性の亢進によって生じた高血糖が骨芽細胞の機能不全を引き起こし、OC、ucOCの産生が低下し、これらの低値を来したと考えられた。OC、ucOC低値は糖尿病とメタボリック症候群の原因ではなく、結果であった。研究成果の概要（英文）：We have conducted a 10-year follow-up survey of the FORMEN cohort study and analyzed the data longitudinally. We have found that low serum levels of osteocalcin (OC) and under-carboxylated OC (ucOC) at baseline were significantly associated with higher odds ratio (OR) of prevalent diabetes mellitus and metabolic syndrome but were not associated with increased OR of incidence of these diseases during the follow-up period. These results do not support that low levels of OC or ucOC induce diabetes mellitus or metabolic syndrome, but suggest that increased insulin tolerance causes hyperglycemia which deteriorates osteoblast function resulting in low production of OC and ucOC. Low levels of OC and ucOC are not a cause of diabetes mellitus or metabolic syndrome but a consequence of them.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2017～2019;   課題番号：17K09141;   研究分野：医学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YURA, Akiko"},{"subitem_text_language":"en","subitem_text_value":"IKI, Masayuki"},{"subitem_text_language":"en","subitem_text_value":"FUJITA, Yuki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"由良, 晶子"},{"creatorName":"ユラ, アキコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"伊木, 雅之"},{"creatorName":"イキ, マサユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"藤田, 裕規"},{"creatorName":"フジタ, ユウキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-15"}],"displaytype":"detail","filename":"17K09141seika.pdf","filesize":[{"value":"143.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17K09141seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/21491/files/17K09141seika.pdf"},"version_id":"1a31df8e-f2b8-449a-93f6-ecebf81fc1a6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"オステオカルシン","subitem_subject_scheme":"Other"},{"subitem_subject":"低カルボキシル化オステオカルシン","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"メタボリック症候群","subitem_subject_scheme":"Other"},{"subitem_subject":"糖代謝","subitem_subject_scheme":"Other"},{"subitem_subject":"予防医学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"オステオカルシン低値は２型糖尿病とメタボリック症候群の発症リスクを高めるか","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オステオカルシン低値は２型糖尿病とメタボリック症候群の発症リスクを高めるか","subitem_title_language":"ja"},{"subitem_title":"Are lower levels of osteocalcin associated with increased risk of incident type 2 diabetes mellitus and metabolic syndrome?","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4613"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-15"},"publish_date":"2021-03-15","publish_status":"0","recid":"21491","relation_version_is_last":true,"title":["オステオカルシン低値は２型糖尿病とメタボリック症候群の発症リスクを高めるか"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-14T02:23:52.505440+00:00"}