{"created":"2023-06-20T16:49:17.929687+00:00","id":21487,"links":{},"metadata":{"_buckets":{"deposit":"45a0f251-c460-4d08-b19f-fac25cf95762"},"_deposit":{"created_by":3,"id":"21487","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"21487"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00021487","sets":["14:2667:4613"]},"author_link":["31890","30535","3386"],"control_number":"21487","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2019)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08580/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：自然界では遭遇しない夜間の光暴露に対してどのような制御があり、中枢神経系がどのような反応を示すか検討を行った。今回、網膜から哺乳類体内時計中枢である視交叉上核（SCN）へ到り、さらにSCNからの投射領域にいたるまで位相依存性に光照射のシグナル伝達が制御されていることが明らかになった。まず、光照射によるSCNのコア領域における神経細胞の興奮が概日リズムによって制御されていることが明らかとなった。さらにこのようなゲートの仕組みが室傍核に及ぶことも明らかになった。さらに、直接光照射を受ける網膜においても位相依存性のゲート機構が存在することを証明した。研究成果の概要（英文）：We examined how the central nervous system responds to light exposure during the night which is absent in the nature. We revealed that the signal transduction of light is controlled in a phase-dependent manner from the retina to the suprachiasmatic nucleus (SCN), which is the center of the mammalian body clock, and further to the projection area from the SCN. First, it was clarified that the excitation of neurons in the core region of the SCN by light exposure is controlled by the circadian rhythm generated by the SCN. Furthermore, it became clear that such a gate mechanism extends to the paraventricular core. Furthermore, it was proved that there is a phase-dependent gating mechanism in the retina that receives direct light exposure.　The findings suggest that light exposure causes an abnormal reaction due to disturbance of circadian rhythm, suggesting that inappropriate light exposure affects not only circadian rhythm but also other central nervous system.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2017～2019;   課題番号：17K08580;   研究分野：時間生物学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SHIGEYOSHI, Yasufumi"},{"subitem_text_language":"en","subitem_text_value":"IKEGAMI, Keisuke"},{"subitem_text_language":"en","subitem_text_value":"SUJINO, Mitsugu"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 助教"},{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"重吉, 康史"},{"creatorName":"シゲヨシ, ヤスフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"池上, 啓介"},{"creatorName":"イケガミ, ケイスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"筋野, 貢"},{"creatorName":"スジノ, ミツグ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-15"}],"displaytype":"detail","filename":"17K08580seika.pdf","filesize":[{"value":"152.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17K08580seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/21487/files/17K08580seika.pdf"},"version_id":"e35c1a0e-0675-483f-817c-fc583309ccbb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"視交叉上核","subitem_subject_scheme":"Other"},{"subitem_subject":"概日リズム","subitem_subject_scheme":"Other"},{"subitem_subject":"ゲート機構","subitem_subject_scheme":"Other"},{"subitem_subject":"光照射","subitem_subject_scheme":"Other"},{"subitem_subject":"光暴露","subitem_subject_scheme":"Other"},{"subitem_subject":"網膜","subitem_subject_scheme":"Other"},{"subitem_subject":"室傍核","subitem_subject_scheme":"Other"},{"subitem_subject":"Bmal1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"不適切環境光入力による概日リズム障害発生機序の究明とその回避方策の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"不適切環境光入力による概日リズム障害発生機序の究明とその回避方策の検討","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"3","path":["4613"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-15"},"publish_date":"2021-03-15","publish_status":"0","recid":"21487","relation_version_is_last":true,"title":["不適切環境光入力による概日リズム障害発生機序の究明とその回避方策の検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-14T02:09:23.516842+00:00"}