{"created":"2023-06-20T16:49:16.290103+00:00","id":21450,"links":{},"metadata":{"_buckets":{"deposit":"bc5c7daa-e014-472c-b011-868a1136ca16"},"_deposit":{"created_by":3,"id":"21450","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"21450"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00021450","sets":["14:2667:4613"]},"author_link":["43309","3809","43310"],"control_number":"21450","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2019)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08432/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：非ステロイド性抗炎症薬 (NSAIDs)誘発性の特異体質性肝障害の発症原因の一つとして、肝臓内で生成されるアシルCoAチオエステル体 (NSAID-CoA)に着目し、生合成や化学的合成を試みたが、その生成は確認できなかった。一方で、NSAIDsは微弱ながらもアシルCoA合成酵素 (ACS)に対する阻害活性を有していた。また、肝障害発症原因の一つであるアシルグルクロン酸抱合体 (AG)についても検討し、酵素によるNSAID-AGの分解が特異体質性毒性と関連すること、マクロファージがAG生成を介したNSAIDsの肝細胞毒性発症に寄与することを明らかにした。研究成果の概要（英文）：We focused on the acyl-CoA thioester metabolites of NSAIDs (NSAID-CoAs) as one of the cause of NSAID-induced idiosyncratic liver injury. Although we attempted to obtain NSAID-CoAs to evaluate their chemical reactivity, we could not synthesized NSAID-CoAs successfully by performing both biological and chemical experiments. On the other hand, NSAIDs inhibited acyl-CoA synthase activity quite weakly. In addition to NSAID-CoA, we also investigated contribution of acyl glucuronide metabolite of NSAIDs (NASID-AGs) to development of NSAID-induced idiosyncratic liver injury. We clarified that the rate constant of enzymatic degradation of NSAID-AGs in rat liver microsomes well concern with the incidence of idiosyncratic toxicity of parent NSAIDs. Moreover, we demonstrated contribution of macrophage to NSAIDs-induced toxicity through AG generation in hepatocyte.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);   研究期間：2017～2019;   課題番号：17K08432;   研究分野：薬物動態学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Iwaki, Masahiro"},{"subitem_text_language":"en","subitem_text_value":"Kawase, Atsushi"},{"subitem_text_language":"en","subitem_text_value":"Shimada, Hiroaki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 教授"},{"subitem_text_value":"近畿大学薬学部; 准教授"},{"subitem_text_value":"近畿大学薬学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岩城, 正宏"},{"creatorName":"イワキ, マサヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"川瀬, 篤史"},{"creatorName":"カワセ, アツシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"島田, 紘明"},{"creatorName":"シマダ, ヒロアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-15"}],"displaytype":"detail","filename":"17K08432seika.pdf","filesize":[{"value":"105.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17K08432seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/21450/files/17K08432seika.pdf"},"version_id":"4c7a1d72-6c37-4dec-adab-57c8b0684971"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"特異体質性肝毒性","subitem_subject_scheme":"Other"},{"subitem_subject":"反応性代謝物","subitem_subject_scheme":"Other"},{"subitem_subject":"非ステロイド性抗炎症薬","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"特異体質性肝障害にアシルCoAチオエステル中間代謝物は関与しているか？","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"特異体質性肝障害にアシルCoAチオエステル中間代謝物は関与しているか？","subitem_title_language":"ja"},{"subitem_title":"Involvement of acyl-CoA thioester metabolite in drug-induced idiosyncratic liver injury","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4613"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-15"},"publish_date":"2021-03-15","publish_status":"0","recid":"21450","relation_version_is_last":true,"title":["特異体質性肝障害にアシルCoAチオエステル中間代謝物は関与しているか？"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-13T05:55:44.390234+00:00"}