{"created":"2023-06-20T16:49:14.699736+00:00","id":21414,"links":{},"metadata":{"_buckets":{"deposit":"7c1cf4e9-e7e8-44d3-8dae-a031f92dfd57"},"_deposit":{"created_by":3,"id":"21414","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"21414"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00021414","sets":["14:2667:4613"]},"author_link":["30676"],"control_number":"21414","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2019)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08481/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：腫瘍内血管は組織内に十分な酸素と栄養素を供給させることでがん細胞を増殖させており、がん細胞が遠隔臓器へ血行性転移する際の経路にもなっている。本研究では、転写因子Dach1 恒常的発現マウス (Dach1-Tg) に形成された腫瘍組織の解析から、Dach1 発現が腫瘍増殖と腫瘍内血管形成に促進的に作用する可能性が明らかになった。また、血管内皮細胞特異的に mTFP1 を発現するレポーターマウスを用いて、Dach1-Tgと野生型マウスに形成された腫瘍組織から単細胞を調製し、フローサイトメトリー法による腫瘍組織内mTFP1 陽性細胞を検出した。研究成果の概要（英文）：Intratumoral blood vessels support cancer cell proliferation by supplying sufficient oxygen and nutrients, and provide cancer cells with a pathway for metastasis. In this study, we revealed that transcription factor Dach1 expression might promote tumor growth and angiogenesis in tumors. We found that tumor with an increased number of blood vessels grow more vigorously in the mice that constantly expressing Dach1 (Dach1-Tg) compared with wild-type. By a fow cytometric analysis using reporter mice that specifically express mTFP1 in vascular endothelial cells, we compared the percentages of endothelial cells in Dach1-Tg- and wild-type-derived tumors.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2016～2019;   課題番号：16K08481;   研究分野：細胞生物学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"HAYASAKA, HARUKO"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学理工学部; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"早坂, 晴子"},{"creatorName":"ハヤサカ, ハルコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-15"}],"displaytype":"detail","filename":"16K08481seika.pdf","filesize":[{"value":"166.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16K08481seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/21414/files/16K08481seika.pdf"},"version_id":"58bb94a0-c587-47b5-888e-b718a5e4aea7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"血管","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍形成","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"特殊血管新生と免疫細胞動員による新規腫瘍抑制機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"特殊血管新生と免疫細胞動員による新規腫瘍抑制機構の解明","subitem_title_language":"ja"},{"subitem_title":"The mechanism underlying tumor inhibition by angiogenesis and immune cell recruitment","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4613"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-15"},"publish_date":"2021-03-15","publish_status":"0","recid":"21414","relation_version_is_last":true,"title":["特殊血管新生と免疫細胞動員による新規腫瘍抑制機構の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-13T01:00:47.051140+00:00"}