{"created":"2023-06-20T16:33:14.839337+00:00","id":2139,"links":{},"metadata":{"_buckets":{"deposit":"3af70825-3eba-4346-a7a2-470c674f8e0d"},"_deposit":{"created_by":3,"id":"2139","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2139"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00002139","sets":["14:2529:2619:2635","21:2532:2621:2636"]},"author_link":["2305"],"item_7_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Morphological and biochemical studies on pathogenesis of vascular changes in transarterial infusion of anti-cancer drugs"}]},"item_7_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"25","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"博士学位論文"},{"bibliographic_title":"Thesis or Dissertation","bibliographic_titleLang":"en"}]}]},"item_7_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[ABSTRACT] To elucidate the pathogenesis of vascular changes caused by transarterial infusion of anti-cancer drugs, the rat hepatic artery and mesenteric artery were examined morphologically and biochemically after cisplatin-lipiodol infusion. Severe degenerative changes were found in endothelial cells as well as medial smooth muscle cells in hepatic and mesenteric arteries. Such changes were milder in the artery in the group administered cisplatinlipiodol and vitamin E (vitamin E group) than in the group administered cisplatin-lipiodol ( cisplatin group) . Superoxide dismutase, a superoxide anion scavenger, was higher in the vitamin E group than in the cisplatin group. Furthermore, Na/K-ATPase, a membrane-related enzyme, was also higher in the vitamin E group. These findings indicate that induced arterial changes were caused by lipid-peroxidation radicals and thus prevented by vitamin E administration.","subitem_description_type":"Abstract"}]},"item_7_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類：医学　　学位授与年月日：1994/3/24　　指導：石田, 修 教授(Director: Prof. Ishida, Osamu)　　報告番号：甲第292号　　学内授与番号：医甲239　　NDL書誌ID：000000278333","subitem_description_type":"Other"}]},"item_7_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_7_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Okafuji, Tatsumasa"}]},"item_7_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学大学院 医学研究科"}]},"item_7_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Department of Radiology, Kinki University School of Medicine"}]},"item_7_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡藤,  龍正"},{"creatorName":"オカフジ, タツマサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2305","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"Thesis_Mek0239-19940324-0001.pdf","filesize":[{"value":"9.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Thesis_Mek0239-19940324-0001.pdf","url":"https://kindai.repo.nii.ac.jp/record/2139/files/Thesis_Mek0239-19940324-0001.pdf"},"version_id":"a56b8b9e-cf29-4693-923c-d10deeda9b08"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"transarterial infusion","subitem_subject_scheme":"Other"},{"subitem_subject":"cisplatin","subitem_subject_scheme":"Other"},{"subitem_subject":"artery","subitem_subject_scheme":"Other"},{"subitem_subject":"free radical","subitem_subject_scheme":"Other"},{"subitem_subject":"superoxide dismutase","subitem_subject_scheme":"Other"},{"subitem_subject":"vitamin E","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"抗癌剤動注による動脈病変の発生機序に関する形態学的および生化学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗癌剤動注による動脈病変の発生機序に関する形態学的および生化学的研究"}]},"item_type_id":"7","owner":"3","path":["2635","2636"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-01-20"},"publish_date":"2014-01-20","publish_status":"0","recid":"2139","relation_version_is_last":true,"title":["抗癌剤動注による動脈病変の発生機序に関する形態学的および生化学的研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T02:15:35.774733+00:00"}