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アトピ-性皮膚炎患者皮膚表皮の最終分化産物の異常について
https://kindai.repo.nii.ac.jp/records/2137
https://kindai.repo.nii.ac.jp/records/2137e543354e-62ce-4dd1-8d68-50e1537b63ef
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Thesis_Mek0212-19940324-0001.pdf (1.8 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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| 公開日 | 2014-01-20 | |||||||||
| タイトル | ||||||||||
| タイトル | アトピ-性皮膚炎患者皮膚表皮の最終分化産物の異常について | |||||||||
| その他（別言語等）のタイトル | ||||||||||
| その他のタイトル | Abnormalities in epidermal terminal differentiation products in skin from patients with atopic dermatitis | |||||||||
| 著者 |
瀬口, 得二
× 瀬口, 得二
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | atopic dermatitis, filaggrin, cystatin A, involucrin, immunohistochemistry, quantitative analysis | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||||||
| 資源タイプ | thesis | |||||||||
| 著者(英) | ||||||||||
| en | ||||||||||
| Seguchi, Tokuji | ||||||||||
| 著者 所属 | ||||||||||
| 近畿大学大学院 医学研究科 内科学系専攻 | ||||||||||
| 著者所属(翻訳) | ||||||||||
| Department of Dermatology, Kinki University School of Medicine | ||||||||||
| 版 | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学 | |||||||||
| 書誌情報 |
博士学位論文 en : Thesis or Dissertation p. 1-29, 発行日 1994-03-01 |
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | [ABSTRACT] Filaggrin, cystatin A and involucrin are the principal products of epidermal terminal differentiation. They are required for normal formation of the stratum corneum. However the surface of the skin of patients with atopic dermatitis is always dry and easily becomes itchy, indicating abnormal stratum corneum formation. This study investigated the cause of the dryness of the skin surface in patients with atopic dermatitis. Paraffin-embedded sections of specimens of skin obtained from 27 patients with atopic dermatitis were labelled with antihuman filaggrin, anti-human cystatin A and anti-human involucrin antibodies, and the amounts of reaction products were determined using a chromatoscanning meter. The amount of filaggrin was 4.89±0.36μg (n＝12) in control skin (NS). In contrast, there were respectively 2.40±0.37μg (n＝12) and 2.91±0.40μg (n＝4) of filaggrin in lesional skin (AD-L) and non-lesional skin (AD-NL) of atopic dermatitis patients. The differences between NS and AD-L and between NS and AD-NL were statistically significant (p<0.001,student t-test). The amount of cystatin A was 4.23±0.37 μg (n＝9) in control skin (NS) and 3.95± 0.14 μg (n＝4) in AD-NL, but 2.13±0.22μg (n＝16) in AD-L, The difference between NS and AD-L was statistically significant. The amount of involucrin was 3.31 ±0.57μg (n＝10) in NS, 3.14±0.54μg(n＝4) in AD-NL, 2.36±0.36μg (n＝16) in AD-L. There were no statistically significant differences between either NS and AD-L or NS and AD-NL in amount of involucrin. These findings suggest that a decrease in the amount of filaggrin, which is the precursor protein for emollient factor (free amino acids) in the stratum corneum, may be one of the causes of dry skin in patients with atopic dermatitis. | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 学位の種類：医学 学位授与年月日：1994/3/24 指導: 手塚, 正 教授(Director: Prof. Tezuka, Tadashi) 報告番号：甲第265号 学内授与番号：医甲212 NDL書誌ID：000000278306 | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
