| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2021-01-18 |
| タイトル |
|
|
タイトル |
<Case Reports> Recurrent atypical cutaneous lesions of IgA vasculitis successfully treated with colchicine: a case report |
|
言語 |
en |
| 著者 |
Yamasaki, Koji
Marutani, Satoshi
Minakata, Shunsuke
Sugimoto, Keisuke
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Immunoglobulin A vasculitis, Colchicine, Relapse, Atypical cutaneous lesions |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
|
|
ID登録 |
10.15100/00021271 |
|
ID登録タイプ |
JaLC |
| 著者 所属 |
|
|
値 |
Department of Pediatrics, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Pediatrics, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Pediatrics, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Pediatrics, Kindai University Faculty of Medicine |
| 版 |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| 出版者 名前 |
|
|
出版者 |
Kindai University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINDAI UNIVERSITY
巻 45,
号 2,
p. 53-57,
発行日 2020-12
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866092 |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
[Abstract] Background: Corticosteroids have a common therapeutic use for recurrent, severe symptoms of Immunoglobulin A vasculitis (IgAV), but several adverse effects are associated with prolonged administration. Colchicine is mentioned as a therapeutic option for cutaneous vasculitis in adults, however only a few cases of colchicine use have been reported in children. Case presentation: A 10-year-old Japanese girl presented typical symptoms of IgAV, consisting of palpable purpura on legs, abdominal pain and knee arthritis. Prednisolone was administrated, but symptoms recurred as prednisone was gradually decreased. Combination with Fibrogammin was also initiated after confirming the decrease of factor XIII activity. As severe cutaneous findings, such as ecchymosis on the right shoulder, upper limbs and lower extremities with cyanotic appearance in right foot, recurred and exacerbated, colchicine was started. Colchicine was dosed up and remained unchanged for 2 months before it was gradually tapered, with gradual improvement of cutaneous manifestations and arthralgia. Colchicine was finally discontinued 5 months after initiation, and no recurrence or renal complication are observed till this date. Conclusions: We presented a case of IgAV that was effectively treated with colchicine for chronic and relapsing atypical cutaneous lesions and arthralgia. Our pathophysiological and preliminary clinical findings support the use and efficacy of colchicine in pediatric patients presenting with chronic and severe cutaneous lesions of IgAV. Further studies are needed in order to clarify the effectiveness and safety of colchicine. |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20201200-0053.pdf (527.5 kB)
