{"created":"2023-06-20T16:33:14.317983+00:00","id":2128,"links":{},"metadata":{"_buckets":{"deposit":"25aac089-d857-4a2c-9db3-2726e81d3c23"},"_deposit":{"created_by":3,"id":"2128","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2128"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00002128","sets":["14:2529:2619:2637","21:2532:2621:2638"]},"author_link":["2294"],"item_7_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Proteinase inhibitors in hamster plasma: Purification, properties and acute phase response"}]},"item_7_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"27","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"博士学位論文"},{"bibliographic_title":"Thesis or Dissertation","bibliographic_titleLang":"en"}]}]},"item_7_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[ABSTRACT] In this study three proteins with trypsin inhibitory activity were purified to apparent homogeneity from hamster plasma and the changes in their plasma level after acute inflammation were examined. α-1 -Antiproteinase had a molecular mass of 68 kDa, and inhibited elastase, trypsin and chymotrypsin but not plasmin, porcine pancreas kallikrein or guinea pig plasma kallikrein. Countertrypin and pre-a-trypsin inhibitor had a molecular mass of 55 kDa and 120 kDa, respectively, and both inhibited only trypsin. The pre-a-trypsin inhibitor consisted of light —1—(25 kDa) and heavy (90 kDa) polypeptide chains, which were dissociated by chondroitinase ABC treatment but not by heating at 100℃ in the presence of sodium dodecyl sulfate and dithiothreitol. Thirteen amino acids of the N-terminal eicosapeptide sequence of both light and heavy chains were identical with the corresponding regions of human serum pre-α-trypsin inhibitor. After induction of inflammation by intraperitoneal injection of Salmonella typhimurium lipopolysaccharide,the plasma level of pre-α-trypsin inhibitor increased and that of murinoglobulin decreased, but other inhibitors showed no significant change.","subitem_description_type":"Abstract"}]},"item_7_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類：医学　　学位授与年月日：1992/6/15　　指導： 篠原, 兵庫 教授(Director: Prof. Sinohara, Hyogo)　　報告番号：乙第172号　　学内授与番号：医乙123　　NDL書誌ID：000000266542","subitem_description_type":"Other"}]},"item_7_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_7_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Amemiya, Shuji"}]},"item_7_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部第二生化学教室"}]},"item_7_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Second Department of Biochemistry, Kinki University School of Medicine"}]},"item_7_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"雨宮,  修二"},{"creatorName":"アメミヤ, シユウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2294","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"Thesis_Meo0123-19920615-0001.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Thesis_Meo0123-19920615-0001.pdf","url":"https://kindai.repo.nii.ac.jp/record/2128/files/Thesis_Meo0123-19920615-0001.pdf"},"version_id":"7833575d-9fe2-48c9-ba75-e0d66a744ee4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"α-1-antiproteinase","subitem_subject_scheme":"Other"},{"subitem_subject":"countertrypin","subitem_subject_scheme":"Other"},{"subitem_subject":"pre-α-trypsin inhibitor","subitem_subject_scheme":"Other"},{"subitem_subject":"hamster plasma","subitem_subject_scheme":"Other"},{"subitem_subject":"acute phase response","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"ハムスター血漿中のプロティナーゼインヒビター--精製と性質及び急性相反応","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ハムスター血漿中のプロティナーゼインヒビター--精製と性質及び急性相反応"}]},"item_type_id":"7","owner":"3","path":["2637","2638"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-06-13"},"publish_date":"2012-06-13","publish_status":"0","recid":"2128","relation_version_is_last":true,"title":["ハムスター血漿中のプロティナーゼインヒビター--精製と性質及び急性相反応"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T02:15:46.387234+00:00"}