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ヒスタミン受容体作動薬のマウスリンパ球抗体産生及びコラ-ゲン関節炎に対する影響
https://kindai.repo.nii.ac.jp/records/2125
https://kindai.repo.nii.ac.jp/records/21257d86777b-d3a3-4fa1-ad78-88d26a31dc2f
| 名前 / ファイル | ライセンス | アクション |
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Thesis_Mek0160-19920319-0001.pdf (662.2 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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| 公開日 | 2011-12-09 | |||||||||
| タイトル | ||||||||||
| タイトル | ヒスタミン受容体作動薬のマウスリンパ球抗体産生及びコラ-ゲン関節炎に対する影響 | |||||||||
| その他（別言語等）のタイトル | ||||||||||
| その他のタイトル | The effects of histamine receptors on IgG production in mice spleen cells and on mice collagen induced arthritis | |||||||||
| 著者 |
藤原, 茂樹
× 藤原, 茂樹
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | histamine receptor, collagen-induced arthritis, type II collagen | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||||||
| 資源タイプ | thesis | |||||||||
| 著者(英) | ||||||||||
| en | ||||||||||
| Fujihara, Shigeki | ||||||||||
| 著者 所属 | ||||||||||
| 近畿大学大学院 医学研究科外科学系専攻 | ||||||||||
| 版 | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学 | |||||||||
| 書誌情報 |
博士学位論文 en : Thesis or Dissertation p. 1-20, 発行日 1992-01-01 |
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | [ABSTRACT] This study was carried out to investigate the role of histamine receptors in IgG production by spleen cells and the effects of histaminergic agonists on type II collagen-induced arthritis in mice. ConA-derived IgG production in the spleen cells from normal DBA/1J mice was dose-dependently suppressed by histamine. Moreover, both of histaminergic H_1 and H_2 agonists suppressed ConA-derived IgG production in the normal spleen cells.In CIA mice, spontaneous IgG production in the spleen cells was significantly higher than that in normal mice, but almost no ConA-derived production was observed in the spleen cells. Histamine induced suppression of the spontaneous IgG production in the spleen cells with CIA was weaker than the histamine-induced suppression on ConA-derived IgG production in the normal spleen cells. The H_2 -agonist-induced suppression on the IgG production in the CIA spleen cells was weaker than that in the normal spleen cells. On the other hand, the Hi -agonist-induced suppression on the IgG production in the CIA spleen cells was stronger than that in the normal spleen cells. Both H_1 and H_2 histaminergic agonists suppressed the incidence of onset with arthritis, arthritic index, and the titer of the anti-type II collagen antibody in CIA mice. The H_1 agonist had stronger benefical effects than the H_2 agonist. These findings suggested that both H_1 and H_2 histaminergic agonists had suppressive effects on in vitro IgG production in the spleen cells and also on in vivo disease activity in CIA. | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 学位の種類：医学 学位授与年月日：1992/3/19 指導：田中, 清介 教授(Director: Prof. Tanaka, Seisuke) 報告番号：甲第207号 学内授与番号：医甲160 NDL書誌ID：000000266465 | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
