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β遮断剤による内因性ANP分泌亢進とその降圧に対する役割
https://kindai.repo.nii.ac.jp/records/2121
https://kindai.repo.nii.ac.jp/records/2121cebff8b3-4f7a-465c-a387-310b11e0e4ee
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Thesis_Meo0169-19950615-0001.pdf (923.7 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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| 公開日 | 2014-01-20 | |||||||||
| タイトル | ||||||||||
| タイトル | β遮断剤による内因性ANP分泌亢進とその降圧に対する役割 | |||||||||
| その他（別言語等）のタイトル | ||||||||||
| その他のタイトル | Influence of β-adrenergic receptor blocking agents on hemodynamics and atrial natriuretic peptide in essential hypertension | |||||||||
| 著者 |
永田, 就三
× 永田, 就三
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | ANP, β-blocker, hypertension, hemodynamics | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||||||
| 資源タイプ | thesis | |||||||||
| 著者(英) | ||||||||||
| en | ||||||||||
| Nagata, Shuzo | ||||||||||
| 著者 所属 | ||||||||||
| 近畿大学医学部 第一内科学教室 | ||||||||||
| 著者所属(翻訳) | ||||||||||
| First Department of Internal Medicine, Kinki University School of Medicine | ||||||||||
| 版 | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学 | |||||||||
| 書誌情報 |
博士学位論文 en : Thesis or Dissertation p. 1-16, 発行日 1996-06-01 |
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | [Abstract]The present study investigated the role of atrial natriuretic peptide (ANP) in the mechanism of anti-hypertensive effects of 13-blockers in patients with essential hypertension. Propranolol and carteolol were used as g-blockers without and with intrinsic sympathominetic activity (ISA). The drugs were administered for 12 weeks in 17 patients. Cardiac output was measured by the dye dilution method. After administration of propranolol, blood pressure, heart rate and cardiac index were significantly reduced (p＜0.05, p＜0.001 and p＜0.01, respectively), and ANP was significantly increased (p＜0.01). A significant negative correlation was observed between percent changes in systolic blood pressure and those in ANP (r＝ —0.594, p＜0.05), whereas no correlation was found between percent changes in systolic blood pressure and those in the cardiac index. The administration of carteolol significantly reduced blood pressure (p＜0.05), without affecting heart rate or cardiac index. Carteolol significantly increased ANP, daily urinary output and creatinine clearances (p＜0.05, p＜0.05 and p＜0.05. respectively). These increases were observed only in the responder group in which carteolol reduced systolic blood pressure by 10 mmHg or more. A positive correlation was noted between ANP and daily urinary output (r＝0.756, p＜0.05). These results indicate thatadministration of propranolol or carteolol stimulate intrinsic ANP secretion regardless of the presence or absence of reduced cardiac function. In conclusion, the anti-hypertensive mechanism of these g-blockers may partially involve depressor diuretic action due to ANP | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 学位の種類：医学 学位授与年月日：1995/6/15 指導：香取, 瞭 教授 報告番号：乙第248号 学内授与番号：医乙169 NDL書誌ID：000000288518 | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
