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Concurrent Generation of Nitric Oxide and Superoxide Inhibits Proteoglycan Synthesis in Bovine Articular Chondrocytes: Involvement of Peroxynitrite
https://kindai.repo.nii.ac.jp/records/2109
https://kindai.repo.nii.ac.jp/records/21098d50e610-5f74-445e-8911-2a870603f9f0
| 名前 / ファイル | ライセンス | アクション |
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Thesis_Me0627-19990323-0001.pdf (2.1 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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| 公開日 | 2014-01-22 | |||||||||
| タイトル | ||||||||||
| タイトル | Concurrent Generation of Nitric Oxide and Superoxide Inhibits Proteoglycan Synthesis in Bovine Articular Chondrocytes: Involvement of Peroxynitrite | |||||||||
| その他（別言語等）のタイトル | ||||||||||
| その他のタイトル | 軟骨細胞におけるIL-1によるPeroxynitriteの誘導とその作用 | |||||||||
| 著者 |
王, 正道
× 王, 正道
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| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | CHONDROCYTES, INTERLEUKIN-1, RHEUMATOID ARTHRITIS | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||||||
| 資源タイプ | thesis | |||||||||
| 著者(英) | ||||||||||
| en | ||||||||||
| O, Masamichi | ||||||||||
| 著者 所属 | ||||||||||
| Graduate School, Kinki University Course of Medicine Department of Orthopaedic Surgery | ||||||||||
| 著者所属(翻訳) | ||||||||||
| 近畿大学大学院 医学研究科 外科学系専攻 | ||||||||||
| 版 | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学 | |||||||||
| 書誌情報 |
博士学位論文 en : Thesis or Dissertation p. 1-8, 発行日 1999-03-01 |
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | [ABSTRACT] Objective. Nitric oxide (NO), widely assumed to be a mediator of interleukin 1 (IL-1), inhibits proteoglycan synthesis in articular chondrocytes. IL-1 also produces superoxide anion. We hypothesized that the IL-1 inhibited proteoglycan synthesis is the result of peroxynitrite formed by the reaction of NO with superoxide. Methods. Bovine articular chondrocytes were cultured in the presence of SIN-1, which leads to simultaneous generation of both NO and superoxide. Proteoglycan synthesis was measured based on the incorporation of 133S1su lfate, and the presence of peroxynitrite was confirmed using immunohistochemistry. Results. SIN-1 inhibited proteoglycan synthesis and superoxide dismutase reversed SIN-1 inhibited proteoglycan synthesis, indicating the simultaneous generation of superoxide is essential to inhibit proteoglycan synthesis. IL-1 induced peroxynitrite in articular chondrocytes and addition of peroxynitrite inhibited proteoglycan synthesis. Conclusion. The concurrent generation of superoxide anion and NO is required for the action of IL-1 to inhibit proteoglycan synthesis. Peroxynitrite is a candidate for this underlying mechanism. Rheumatol 1998;25:2169-74) | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 学位の種類：医学 学位授与年月日：1999/3/23 指導： 田中, 清介 教授(Director: Prof. Tanaka, Seisuke) 報告番号：甲第477号 学内授与番号：医627 NDL書誌ID：000000335677 | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
