{"created":"2023-06-20T16:33:13.352409+00:00","id":2107,"links":{},"metadata":{"_buckets":{"deposit":"bcf7d848-f60e-496e-9691-418ee9be2059"},"_deposit":{"created_by":3,"id":"2107","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2107"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00002107","sets":["14:2529:2619:2627","21:2532:2621:2628"]},"author_link":["2273"],"item_7_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Relation between Th1/Th2 cytokines production and development of diabetes mellitus in NOD mice"}]},"item_7_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"15","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"博士学位論文"},{"bibliographic_title":"Thesis or Dissertation","bibliographic_titleLang":"en"}]}]},"item_7_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[抄録] ヒトの1型糖尿病のモデルであるNODマウスにおいては糖尿病発症に性差があり, 過去のデータが示すようにcyclophosphamide(CY)が糖尿病発症を促進する. CY投与雌雄NODマウスにおける糖尿病発症とTh1サイトカインであるIL-2, IFN一γ およびTh2サイトカインであるIL-4, IL40産生能との関係を検討した.その結果, NODマウスではCY処理により上記4種サイトカインはいずれも産生能の増加を認めたが, その産生パター一ンには差があり, Th2/Th1サイトカイン比の不均衡を生じた. CY投与雌NODマウスでは投与1週後よりも2週後にIL-2(Th1サイトカイン)の産生能増加を示した. CY投与2週後の観察では, saline投与群と比較してIL-10/IL-2比の有意な低下を認め, 糖尿病発症をみた.本実験により, CYが雌NODマウスのTh1サイトカインとTh2サイトカインの不均衡を生じ, そのことが糖尿病発症を促進する一因となる可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_7_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類：医学　　学位授与年月日：1999/3/23　　指導：青木, 矩彦 教授(Director: Prof. Aoki, Norihiko)　　報告番号：甲第491号　　学内授与番号：医641　　NDL書誌ID：000000335691　　　　実験協力者：大野, 恭裕(Ono, Yasuhiro)   今村, 稔(Imamura, Minoru)","subitem_description_type":"Other"}]},"item_7_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_7_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Yamauchi, Takaaki"}]},"item_7_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学大学院医学研究科 内科学系専攻"}]},"item_7_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Second Department of Internal of Medicine, Kinki University School of Medicine"}]},"item_7_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山内,  孝哲"},{"creatorName":"ヤマウチ, タカアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"Thesis_Me0641-19990323-0001.pdf","filesize":[{"value":"963.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Thesis_Me0641-19990323-0001.pdf","url":"https://kindai.repo.nii.ac.jp/record/2107/files/Thesis_Me0641-19990323-0001.pdf"},"version_id":"d6ad046e-caf8-4e46-ae82-4810f2435c64"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"NOD mice","subitem_subject_scheme":"Other"},{"subitem_subject":"T-lymphocyte","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin 2","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin 4","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin 10","subitem_subject_scheme":"Other"},{"subitem_subject":"interferon γ","subitem_subject_scheme":"Other"},{"subitem_subject":"type 1DM","subitem_subject_scheme":"Other"},{"subitem_subject":"cyclophosphamide","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"NODマウスにおけるTh2サイトカインおよびTh2サイトカイン産生能と糖尿病発症との関係","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"NODマウスにおけるTh2サイトカインおよびTh2サイトカイン産生能と糖尿病発症との関係"}]},"item_type_id":"7","owner":"3","path":["2627","2628"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-12-09"},"publish_date":"2011-12-09","publish_status":"0","recid":"2107","relation_version_is_last":true,"title":["NODマウスにおけるTh2サイトカインおよびTh2サイトカイン産生能と糖尿病発症との関係"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-21T02:16:13.807045+00:00"}