{"created":"2023-06-20T16:48:41.898933+00:00","id":20710,"links":{},"metadata":{"_buckets":{"deposit":"8d799685-6a51-4eba-ae5e-5a437df4e8c3"},"_deposit":{"created_by":3,"id":"20710","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20710"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00020710","sets":["14:2667:4550"]},"author_link":["30545","4195"],"control_number":"20710","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2018)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K01401/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：当該研究課題では、Fイオンをドープした分散性と結晶性が高く、微弱な抗菌性を有しアナフィラキシー（様）反応を回避するF-HApナノ粒子を開発し、新規な抗感染性カテーテル創出のための基盤技術を確立した。当該ナノ粒子の性能評価として、Fイオンの放出挙動、病原性微生物を用いた抗菌性評価、線維芽細胞(L929細胞)を用いた接着性評価、およびプロトタイプ作製のためのカテーテル素材へのコーティング（複合化）の検討を実施した。以上の結果から、多種の細菌に微弱な抗菌性を有しつつも正常細胞に対して毒性が低く、またカテーテル素材へのコーティング好適な抗菌性ナノ粒子の創出を達成した。研究成果の概要（英文）：In this research, a basic technology of antibacterial coating with nano-materials was established to aim at fabricating a novel anti-infection catheter by development of fluorine(F)-ion doped hydroxyapatite (F-HAp) nanoparticles possessing highly crystalline, dispersible, and weak antibacterial activity. The material especially leaved from expression of anaphylactoid reaction. Several kinds of chemical and biological evaluations, such as F-ion releasing test, anti-bacterial test using several types of bacteria, cell adhesion test with fibroblast cells (L929 cells), and examination of nano-coating on the substrate of catheter to fabricate prototype model were conducted. In conclusion, novel anti-bacterial nanoparticles were finally developed showing weak anti-bacterial activity against several bacteria, non-toxicity for normal cells, and suitable for coating on catheter substrate.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2016～2018;   課題番号：16K01401;   研究分野：生体医工学・生体材料学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"FURUZONO, Tsutomu"},{"subitem_text_language":"en","subitem_text_value":"AZUMA, Yoshinao"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学生物理工学部; 教授"},{"subitem_text_value":"近畿大学生物理工学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古薗, 勉"},{"creatorName":"フルゾノ, ツトム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"30545","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30332406","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=30332406"}]},{"creatorNames":[{"creatorName":"東, 慶直"},{"creatorName":"アズマ, ヨシナオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4195","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90333509","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=90333509"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-12"}],"displaytype":"detail","filename":"16K01401seika.pdf","filesize":[{"value":"491.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16K01401seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/20710/files/16K01401seika.pdf"},"version_id":"5b27a746-9baf-4c45-9cab-eeeab62ca0a1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"抗菌性","subitem_subject_scheme":"Other"},{"subitem_subject":"アナフィラキシー","subitem_subject_scheme":"Other"},{"subitem_subject":"ナノマテリアル","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アナフィラキシー回避型抗菌性ナノマテリアルの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アナフィラキシー回避型抗菌性ナノマテリアルの開発","subitem_title_language":"ja"},{"subitem_title":"Development of antibacterial nano-materials leaving from anaphylaxis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4550"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"20710","relation_version_is_last":true,"title":["アナフィラキシー回避型抗菌性ナノマテリアルの開発"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-21T04:35:02.643143+00:00"}