{"created":"2023-06-20T16:48:41.763986+00:00","id":20707,"links":{},"metadata":{"_buckets":{"deposit":"efe36338-981a-43bd-a2d4-25f4f5ff7423"},"_deposit":{"created_by":3,"id":"20707","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20707"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00020707","sets":["14:2667:4550"]},"author_link":["31910","43082"],"control_number":"20707","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2018)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K18256/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要(和文):骨粗鬆症の病態には明らかな性差があり、性ホルモン以外の要因も骨代謝の性差に関与する可能性が示唆されてきた。マウス初代培養骨芽細胞表現型における性差を検討したところ、分化や石灰化は、雄と比較して雌において著明に低かった。このような骨芽細胞の性差を決定する因子の探索を行ったところ、最も雌に発現量が優位に高い遺伝子として、Serpina3nを同定した。雌の骨芽細胞に優位に発現するSerpina3nは、分化した骨芽細胞における表現型を抑制する作用を有し、マウスの骨芽細胞表現型や骨粗鬆症病態の性差を部分的に説明する可能性が考えられた。研究成果の概要(英文):It has been suggested that factors other than sex hormones may also be involved in sex differences in osteoporosis and bone metabolism. In primary mouse osteoblasts, the differentiation and calcification were significantly lower in females than males. We performed the comprehensive gene expression analyses and Serpina3n was identified as a gene whose expression level is predominantly higher in females than males. While the reduced endogenous Serpina3n significantly enhanced osteoblast differentiation, enhanced Serpina3n significantly suppressed osteoblast differentiation in a mouse osteoblast cell line. In addition, Serpina3n did not affect the differentiation of mouse mesenchymal stem cell line into osteoblasts, but significantly suppressed calcification. From the above results, Serpina3n, which is predominantly expressed in female osteoblasts, suppresses the phenotype in differentiated osteoblasts. It would be partially able to explain sex differences in osteoblast phenotypes.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目:若手研究(B); 研究期間:2017~2018; 課題番号:17K18256; 研究分野:骨代謝; 科研費の分科・細目:","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Ishida, Masayoshi"},{"subitem_text_language":"en","subitem_text_value":"Kaji, Hiroshi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石田, 昌義"},{"creatorName":"イシダ, マサヨシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"31910","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50643251","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=50643251"}]},{"creatorNames":[{"creatorName":"梶, 博史"},{"creatorName":"カジ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43082","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-12"}],"displaytype":"detail","filename":"17K18256seika.pdf","filesize":[{"value":"684.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17K18256seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/20707/files/17K18256seika.pdf"},"version_id":"3c7de9ac-e852-44a7-b3c0-71a8e84808af"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"閉経後骨粗鬆症","subitem_subject_scheme":"Other"},{"subitem_subject":"骨芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"骨代謝","subitem_subject_scheme":"Other"},{"subitem_subject":"性差","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"骨芽細胞における骨粗鬆症発症を規定する斬新的な性差因子探索と発症メカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨芽細胞における骨粗鬆症発症を規定する斬新的な性差因子探索と発症メカニズムの解明","subitem_title_language":"ja"},{"subitem_title":"Exploring the novel sex-dependent factors in osteoblastic cells to clarify the mechanisms on developing the osteoporosis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4550"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"20707","relation_version_is_last":true,"title":["骨芽細胞における骨粗鬆症発症を規定する斬新的な性差因子探索と発症メカニズムの解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-21T04:25:26.863162+00:00"}