{"created":"2023-06-20T16:48:41.718780+00:00","id":20706,"links":{},"metadata":{"_buckets":{"deposit":"d0fa24ff-4fa4-493b-8f9d-01411bc9a3d0"},"_deposit":{"created_by":3,"id":"20706","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20706"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00020706","sets":["14:2667:4550"]},"author_link":["43080","43081"],"control_number":"20706","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2018)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K16873/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：悪性腫瘍は様々なゲノム形質を有する細胞で構成されており、これを腫瘍内不均一性卵巣高異型度漿液性癌(HGSOC)は、約半数で相同組換修復(HRR)という遺伝子修復機構に異常が認められという。HGSOCのゲノムデータを解析し、腫瘍内不均一性とHRRの異常を数値化して検討を行い、腫瘍内不均一性とHRR異常が予後の関連性があること、化学療法前後で腫瘍内不均一性が減少すること、そして治療の時系列でHRR異常のスコアが変化する場合があることを明らかにした。研究成果の概要（英文）：The malignant tumor consists of cancer cells which have various genomic phenotype, that is called intratumor heterogeneity. Almost half of high grade serous ovarian cancer (HGSOC) have disfunction of homologous recombination repair which is one of DNA repair pathway. We have analyzed genomic data of HGSOC to quantify the degree of intratumor heterogeneity and homologous recombination repair deficiency (HRD). We have revealed that intratumor heterogeneity and HRD were associated with prognosis and intratumor heterogeneity was reduced after chemotherapy and HRD score changed throughout time course of treatment in some cases.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2016～2018;   課題番号：17K16873;   研究分野：婦人科腫瘍学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Takaya, Hisanitsu"},{"subitem_text_language":"en","subitem_text_value":"Matsumura, Noriomi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高矢, 寿光"},{"creatorName":"タカヤ, ヒサミツ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"松村, 謙臣"},{"creatorName":"マツムラ, ノリオミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-12"}],"displaytype":"detail","filename":"17K16873seika.pdf","filesize":[{"value":"323.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17K16873seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/20706/files/17K16873seika.pdf"},"version_id":"2dee7b48-37b7-41e7-895e-b10bd5533743"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"卵巣癌","subitem_subject_scheme":"Other"},{"subitem_subject":"がんゲノム","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍内不均一性","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"卵巣癌のliquid biopsyによる新たなスクリーニング法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"卵巣癌のliquid biopsyによる新たなスクリーニング法の確立","subitem_title_language":"ja"},{"subitem_title":"The establishment of new method of screening with liquid biopsy for ovarian cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4550"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"20706","relation_version_is_last":true,"title":["卵巣癌のliquid biopsyによる新たなスクリーニング法の確立"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-21T04:22:35.097168+00:00"}