{"created":"2023-06-20T16:48:41.673117+00:00","id":20705,"links":{},"metadata":{"_buckets":{"deposit":"4c19de95-7c99-439f-9d7f-d7759c3ef3c1"},"_deposit":{"created_by":3,"id":"20705","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20705"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00020705","sets":["14:2667:4550"]},"author_link":["43078","43079"],"control_number":"20705","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2018)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K13039/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究は,全身のリンパ節がヒトのリンパ節と同等のリンパ節サイズ(長径10mm)にまで腫脹するリンパ節腫脹マウスMXH10/Mo-lpr/lprを用いて転移リンパ節モデルの作製とその治療手法の確立をおこなった.上流リンパ節である腸骨下リンパ節ヘドキソルビシンと微小気泡の混合液を注射すると側腹部リンパ管を介して下流の転移腋窩リンパ節へ送達されることが高周波超音波診断で確認された.ここで外部から超音波を照射すると微小気泡の破壊によりドキソルビシンが転移リンパ節内の辺縁洞腫瘍に効果的に導入されていることが明らかになり,高い抗腫瘍効果が得られることを示した。研究成果の概要（英文）：Our study used MXH10/Mo-lpr/lpr mice, which develop systemic swelling of lymph nodes up to 10mm in diameter. Murine breast cancer cells were inoculated into the subiliac lymph node of these mice to deliver them to the downstream proper axillary lymph node, thereby developing a model of a metastatic lesion. In order to deliver doxorubicin(Dox) to the tumor lesions in the proper axillary lymph node via the lymphatic vessels, solutions containing Dox and nano/microbubbles were injected into the subiliac lymph node. After successful detection of nano/microbubbles in the proper axillary lymph node, the bubbles were destroyed by the application of destruction ultrasound; this resulted in the penetration of Dox into tumor tissues in the marginal sinuses and enhancement of its antitumor effects. This study is unique in that the treatment technique described was able to suppress the intranodal invasion of tumor cells and thereby preserve the lymphatic structure in the tumor-bearing lymph node.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2017～2018;   課題番号：17K13039;   研究分野：人口医工学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Kato, Shigeki"},{"subitem_text_language":"en","subitem_text_value":"Kodama, Tetsuya"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"加藤, 茂樹"},{"creatorName":"カトウ, シゲキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"小玉, 哲也"},{"creatorName":"コダマ, テツヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-12"}],"displaytype":"detail","filename":"17K13039seika.pdf","filesize":[{"value":"505.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17K13039seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/20705/files/17K13039seika.pdf"},"version_id":"d5737810-ff09-40ff-941e-8d32f48f6548"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ドラッグデリバリー","subitem_subject_scheme":"Other"},{"subitem_subject":"超音波","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍免疫","subitem_subject_scheme":"Other"},{"subitem_subject":"リンパ節転移","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"リンパ行性薬剤投与と超音波によるリンパ球への遺伝子導入とがん免疫療法への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"リンパ行性薬剤投与と超音波によるリンパ球への遺伝子導入とがん免疫療法への応用","subitem_title_language":"ja"},{"subitem_title":"Gene delivery into lymphocytes using lymphatic administration and ultrasound","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4550"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"20705","relation_version_is_last":true,"title":["リンパ行性薬剤投与と超音波によるリンパ球への遺伝子導入とがん免疫療法への応用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-21T04:15:14.264066+00:00"}