{"created":"2023-06-20T16:48:41.290071+00:00","id":20699,"links":{},"metadata":{"_buckets":{"deposit":"bf6e89b4-2258-4949-b7bf-5893d00b27a0"},"_deposit":{"created_by":3,"id":"20699","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20699"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00020699","sets":["14:2667:4550"]},"author_link":["30522","30524","30523","3699"],"control_number":"20699","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2018)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K11389/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：これまでの耳介形状軟骨の再生誘導に関する研究において、ヒト由来の軟骨細胞を用いた報告は数少なく、ヒト耳介軟骨細胞から耳介特有の質感を反映する軟骨再生が可能かどうか、さらに小耳症軟骨を細胞供給源として利用することは可能かどうかに関しては、未解決な問題として残されている。そこで、本研究では、ヒト耳介軟骨の性状に近いたち耳軟骨および小耳症軟骨の2種類のヒト耳介由来軟骨組織から単離した軟骨細胞を用いて再生誘導を試みた。その結果、小耳症軟骨細胞を細胞供給源とする再生軟骨の成熟過程は、正常軟骨と同様な過程を経て進行することが判明した。研究成果の概要（英文）：In previous studies on the regeneration of auricle-shaped cartilage by tissue engineering, it remained unresolved whether it is possible to regenerate cartilage reflecting the characteristic texture of the auricle using human auricular chondrocytes and microtia cartilage as a cell source. Ln this study, we attempted regeneration by combining chondrocytes isolated from the human protruding ear cartilage with almost normal auricular cartilage properties and human microtia cartilage with nanofiber PGA, and compared the long-term results of the regenerated cartilage. Cartilage could be regenerated from human auricular chondrocytes in both groups, and a favorable shape and expression of cartilage-related genes were maintained for a prolonged period after transplantation.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2016～2018;   課題番号：16K11389;   研究分野：医歯薬学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Isogai, Noritaka"},{"subitem_text_language":"en","subitem_text_value":"Morotomi, Tadaaki"},{"subitem_text_language":"en","subitem_text_value":"Kusuhara, Hirihisa"},{"subitem_text_language":"en","subitem_text_value":"Asamura, Shinichi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 准教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"和歌山県立医科大学医学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"磯貝, 典孝"},{"creatorName":"イソガイ, ノリタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"諸富, 公明"},{"creatorName":"モロトミ, タダアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"楠原, 廣久"},{"creatorName":"クスハラ, ヒロヒサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"朝村, 真一"},{"creatorName":"アサムラ, シンイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-12"}],"displaytype":"detail","filename":"16K11389seika.pdf","filesize":[{"value":"547.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16K11389seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/20699/files/16K11389seika.pdf"},"version_id":"60b461da-c24f-49f9-af17-fc8d03ac8a10"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"小耳症","subitem_subject_scheme":"Other"},{"subitem_subject":"軟骨再生","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"小耳症軟骨細胞を用いて誘導した再生軟骨とその長期移植成績","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"小耳症軟骨細胞を用いて誘導した再生軟骨とその長期移植成績","subitem_title_language":"ja"},{"subitem_title":"Long term results of tissue-engineered cartilage regenerated by nanoPGA scaffolds seeded with human prominent and microtia chondrocytes","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4550"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"20699","relation_version_is_last":true,"title":["小耳症軟骨細胞を用いて誘導した再生軟骨とその長期移植成績"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-21T02:17:25.379489+00:00"}