{"created":"2023-06-20T16:48:40.756131+00:00","id":20691,"links":{},"metadata":{"_buckets":{"deposit":"d1aeddbe-efd8-4e76-99b4-d9a013b0a22e"},"_deposit":{"created_by":3,"id":"20691","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20691"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00020691","sets":["14:2667:4550"]},"author_link":["43054","43055","43056"],"control_number":"20691","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2018)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09465/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：「バゾプレッシン系と交感神経系のクロストークを心腎脳ネットワークの観点より検討し、その修飾による新規治療の可能性を探ること」を目的とした。心不全モデル動物では、腎臓交感神経切除術、β遮断薬のみならず、イバブラジンも全身および心臓感神経活動を抑制すること、更にはそれを介しバゾプレッシン系にも作用することを明らかにしクロストークの存在を明らかにした。また敗血症性臓器障害モデルにて、腎臓交感神経切除術は心機能障害の発現および生命予後を改善すること、バゾプレッシン受容体ノックアウトマウスでは、更なる心腎機能改善および生命予後改善がもたらされることを明らかにし、両システム遮断の相乗効果も存在した。研究成果の概要（英文）：The purpose of this study was to examine the crosstalk between the vasopressin system and the sympathetic nervous system from the viewpoint of the heart-kidney-brain network, and to explore the possibility of new treatment by its modification. In the heart failure model animals, not only renal denervation and β-blocker, but also ivabradine suppressed systemic and cardiac sympathetic activities, and we clarified the presence of crosstalk by the findings that they also acted on vasopressin system through it. Also, in the septic organ failure model, by renal denervation to improve the progression of cardiac dysfunction and prognosis, the vasopressin receptor knockout mice revealed the further improvement of cardiac/renal function and prognosis. The synergistic effect of both systems was also observed. It was not only shown that the control of the cardiorenal interaction was useful, but the possibility of the new treatment in both pathologies was suggested.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2016～2018;   課題番号：16K09465;   研究分野：循環器内科;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究協力者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Iwanaga, Yoshitaka"},{"subitem_text_language":"en","subitem_text_value":"Ono, koh"},{"subitem_text_language":"en","subitem_text_value":"Yamamoto, hiromi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岩永, 善高"},{"creatorName":"イワナガ, ヨシタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"尾野, 亘"},{"creatorName":"オノ, コウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山本, 裕美"},{"creatorName":"ヤマモト, ヒロミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-12"}],"displaytype":"detail","filename":"16K09465seika.pdf","filesize":[{"value":"338.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16K09465seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/20691/files/16K09465seika.pdf"},"version_id":"984f4111-ddbd-4ce7-be76-768761497b7f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"バゾプレッシン","subitem_subject_scheme":"Other"},{"subitem_subject":"交感神経系","subitem_subject_scheme":"Other"},{"subitem_subject":"心腎脳連関","subitem_subject_scheme":"Other"},{"subitem_subject":"心不全","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"心腎脳連関におけるバゾプレッシン系と交感神経系のクロストークの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"心腎脳連関におけるバゾプレッシン系と交感神経系のクロストークの解明","subitem_title_language":"ja"},{"subitem_title":"the crosstalk between the vasopressin system and the sympathetic nervous system from the viewpoint of the heart-kidney-brain network","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4550"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"20691","relation_version_is_last":true,"title":["心腎脳連関におけるバゾプレッシン系と交感神経系のクロストークの解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-20T07:52:55.804609+00:00"}