{"created":"2023-06-20T16:48:40.695836+00:00","id":20690,"links":{},"metadata":{"_buckets":{"deposit":"a3b79789-3c9a-453c-ab13-dd03f6690c8e"},"_deposit":{"created_by":3,"id":"20690","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20690"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00020690","sets":["14:2667:4550"]},"author_link":["33539","43051","43052","43053"],"control_number":"20690","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2018)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09382/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：肝癌切除例のゲノム、エピゲノム、クロモゾームの包括的解析から肝癌組織をサブクラス分類し、術後に転移再発が生じやすいサブクラスと、その遺伝子変化の特徴を明らかにした。次に、その遺伝子変化の特徴を基に、転移再発を予測する分子スコアリングを確立した。このスコアは、肝癌の肝移植例のコホートにおいて、移植後の転移再発と関連した。また、公共データベースThe Cancer Genome Atlasに登録されている肝癌治癒切除例において、今回開発した分子スコアを検討したところ、肝切除後の無再発生存期間と関連した。肝癌遺伝子変化の統合解析により確立した肝癌の分子スコアリングは、転移再発予測に有用である。研究成果の概要（英文）:We clarify molecular features of aggressive HCC, and establish a molecular scoring system that predicts metastasis after curative treatment. In total, 125 HCCs were examined for genome methylome and chromosomal analyses; molecular subclasses and risk score were determined. Next, HCC patients who underwent liver transplantation were analyzed for molecular risk score and metastatic recurrence; survival analyses were validated using a dataset of 376 HCC cases from the Cancer Genome Atlas (TCGA). Molecular risks, that consisted with presence of TP53 mutation, high FAL, global hypomethylation, and absence of CTNNB1 mutation were noted to predict shorter recurrence-free survival in both liver transplantation cohort (p = 0.0090 by log-rank test). And TCGA cohort (p = 0.0076). We concluded that molecular score could predict metastatic recurrence after curative treatments, and could be a marker for considering systemic therapy for HCC patients.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2016～2018;   課題番号：16K09382;   研究分野：消化器内科学、肝臓病学、臨床腫瘍学、分子生物学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究協力者"},{"subitem_text_value":"研究協力者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"NISHIDA, Naoshi"},{"subitem_text_language":"en","subitem_text_value":"KUDO, Masatoshi"},{"subitem_text_language":"en","subitem_text_value":"KAIDO, Toshimi"},{"subitem_text_language":"en","subitem_text_value":"TANAKA, Shinji"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西田, 直生志"},{"creatorName":"ニシダ, ナオシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"工藤, 正俊"},{"creatorName":"クドウ, マサトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"海道, 利実"},{"creatorName":"カイドウ, トシミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 真二"},{"creatorName":"タナカ, シンジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-12"}],"displaytype":"detail","filename":"16K09382seika.pdf","filesize":[{"value":"108.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16K09382seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/20690/files/16K09382seika.pdf"},"version_id":"f62d450c-a824-4866-91f9-cc9222df9330"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肝細胞癌","subitem_subject_scheme":"Other"},{"subitem_subject":"転移","subitem_subject_scheme":"Other"},{"subitem_subject":"ゲノム","subitem_subject_scheme":"Other"},{"subitem_subject":"エピゲノム","subitem_subject_scheme":"Other"},{"subitem_subject":"クロモゾーム","subitem_subject_scheme":"Other"},{"subitem_subject":"化学療法","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"メチローム・クロモゾーム解析に基づく肝癌転移関連分子の同定と臨床応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"メチローム・クロモゾーム解析に基づく肝癌転移関連分子の同定と臨床応用","subitem_title_language":"ja"},{"subitem_title":"Identification of metastasis-associated genes based on methylome and chromosome analyses and it's clinical application","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4550"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"20690","relation_version_is_last":true,"title":["メチローム・クロモゾーム解析に基づく肝癌転移関連分子の同定と臨床応用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-20T07:49:59.465751+00:00"}