{"created":"2023-06-20T16:48:40.512674+00:00","id":20686,"links":{},"metadata":{"_buckets":{"deposit":"5ea7125a-d44a-471b-8163-32dff55060f4"},"_deposit":{"created_by":3,"id":"20686","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20686"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00020686","sets":["14:2667:4550"]},"author_link":["30536"],"control_number":"20686","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2018)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08723/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：Cell adhesion molecule 1 (CADM1)は神経細胞に高発現する接着分子で、神経軸索と髄鞘との接着を司りシナプス形成に必須の分子である。本研究では担癌によって管腔が拡張した大腸癌手術検体の腸管神経系では、腸管の拡張率(腸内圧)上昇によって神経節細胞数および神経線維密度が減少し、CADM1の細胞膜上での酵素的切断が亢進していることを見出した。独自に開発した圧力負荷培養装置を用いて、圧力上昇によってCADM1の切断が亢進し、切断断片が神経線維上に蓄積凝集することによって神経変性を招くことを実験的に証明した。また、切断断片の凝集には特定のアミノ酸配列が関わることも示した。研究成果の概要（英文）：CADM1 is an adhesion molecule expressed abundantly in neurons and epithelial cells. We have revealed that ectodomain shedding of CADM1 is occurred in emphysema, interstitial pneumonia and diabetes and that CADM1 shedding leads to cell apoptosis. In this study, to elucidate pathogenic action of CADM1 shedding in neurodegeneration, we investigated the correlation between enteric nerve degeneration and CADM1 shedding in dilated colon with tumor-induced stenosis. CADM1 shedding rate was increased proportionately with colon dilation in association with decrease of ganglion cells and neurites. Using two-chamber cell culture system enable to loading modest static pressure to the cultured cells, we showed that increasing pressure induced CADM1 shedding and the decreases of neurite density and thickness. Exogenous expression of CADM1 shedding product resulted in neurites loss, suggesting its involvement in neurodegeneration.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2016～2018;   課題番号：16K08723;   研究分野：実験病理学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YONESHIGE, Azusa"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"米重, あづさ"},{"creatorName":"ヨネシゲ, アヅサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"30536","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70586750","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=70586750"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-12"}],"displaytype":"detail","filename":"16K08723seika.pdf","filesize":[{"value":"735.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16K08723seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/20686/files/16K08723seika.pdf"},"version_id":"a5baa19c-0485-49b1-996e-7140913766ca"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"神経変性","subitem_subject_scheme":"Other"},{"subitem_subject":"接着分子","subitem_subject_scheme":"Other"},{"subitem_subject":"腸管神経系","subitem_subject_scheme":"Other"},{"subitem_subject":"緑内障","subitem_subject_scheme":"Other"},{"subitem_subject":"病的内圧上昇","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"糖尿病に伴う腸管神経変性における接着分子CADM1の病的意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"糖尿病に伴う腸管神経変性における接着分子CADM1の病的意義","subitem_title_language":"ja"},{"subitem_title":"Pathogenic action of CADM1 shedding in neurodegeneration","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4550"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"20686","relation_version_is_last":true,"title":["糖尿病に伴う腸管神経変性における接着分子CADM1の病的意義"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-20T07:32:26.820446+00:00"}