{"created":"2023-06-20T16:48:40.427483+00:00","id":20684,"links":{},"metadata":{"_buckets":{"deposit":"31919dae-8084-4b48-99e4-e802c9781002"},"_deposit":{"created_by":3,"id":"20684","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20684"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00020684","sets":["14:2667:4550"]},"author_link":["3167","3715","43044","43045"],"control_number":"20684","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2018)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08534/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、メカニカルストレスによって誘導される筋と骨のネットワークに寄与する因子を探索し、脂肪が筋と骨のネットワークにおよぼす影響を検討した。今回、過重力負荷によって筋で産生され、骨代謝に影響を及ぼす因子としてフォリスタチンを見出し、フォリスタチンは、骨に正の作用を有することを明らかにした。さらに、非荷重による骨量減少に筋でのアイリシン産生減少が関与することが示唆された。また、肥満は非荷重によって減少した骨量、筋量、筋力の再荷重による回復を促進させることを見出し、アディポカインとしてのレプチンが肥満による筋と骨の回復促進に寄与することが示唆された。研究成果の概要（英文）：We aimed to investigate the humoral factors linking muscle to bone induced by mechanical stress and effects of obesity on the relationships between muscle and bone. We found that hypergravity increased follistatin levels in skeletal muscle. Follistatin may have beneficial effects on bone metabolism as a humoral factor linking muscle to bone. Moreover, we reported that mechanical unloading reduced irisin expression in the skeletal muscle of mice and irisin may contribute to disuse-induced bone loss in mice. We also found that obesity enhances the recovery of bone and muscle masses as well as strength decreased by disuse after reloading in mice. Leptin may be involved in the recovery of muscle and bone enhanced by obesity in mice.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2016～2018;   課題番号：16K08534;   研究分野：生理学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究協力者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Kawao, Naoyuki"},{"subitem_text_language":"en","subitem_text_value":"Kaji, Hiroshi"},{"subitem_text_language":"en","subitem_text_value":"Morita, Hironobu"},{"subitem_text_language":"en","subitem_text_value":"Okumoto, Katsumi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河尾, 直之"},{"creatorName":"カワオ, ナオユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"梶, 博史"},{"creatorName":"カジ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"森田, 啓之"},{"creatorName":"モリタ, ヒロノブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"奥本, 勝美"},{"creatorName":"オクモト, カツミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-12"}],"displaytype":"detail","filename":"16K08534seika.pdf","filesize":[{"value":"125.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16K08534seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/20684/files/16K08534seika.pdf"},"version_id":"89e02bb8-0f41-4335-a181-15388dbd2b92"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨粗鬆症","subitem_subject_scheme":"Other"},{"subitem_subject":"サルコペニア","subitem_subject_scheme":"Other"},{"subitem_subject":"筋骨関連","subitem_subject_scheme":"Other"},{"subitem_subject":"肥満","subitem_subject_scheme":"Other"},{"subitem_subject":"脂肪","subitem_subject_scheme":"Other"},{"subitem_subject":"メカニカルストレス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脂肪蓄積による筋と骨のネットワーク破綻メカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脂肪蓄積による筋と骨のネットワーク破綻メカニズムの解明","subitem_title_language":"ja"},{"subitem_title":"Dysfunction in relationships between muscle and bone in obesity","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4550"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"20684","relation_version_is_last":true,"title":["脂肪蓄積による筋と骨のネットワーク破綻メカニズムの解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-20T07:26:35.770267+00:00"}