{"created":"2023-06-20T16:48:40.342835+00:00","id":20682,"links":{},"metadata":{"_buckets":{"deposit":"41c6f5a0-d616-489d-a675-b64eba6cfc38"},"_deposit":{"created_by":3,"id":"20682","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20682"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00020682","sets":["14:2667:4550"]},"author_link":["30484"],"control_number":"20682","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2018)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07073/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、オリゴデンドロサイト特異的かつ慢性ストレス特異的なリン酸化シグナルに対する制御因子としてのアルギニンメチル化の新規役割を解明し、オリゴデンドロサイト機能維持によるうつ病性疾患や不安障害の治療・予防への応用に展開するための研究基盤を確立することを目的とした。本研究課題では、慢性ストレス暴露におけるPRMTファミリーのひとつと想定されるアルギニンメチル化の低下とPI3Kシグナルの活性化が生じている可能性を見出すと共に、RNA結合タンパク質のひとつがメチル化制御されている可能性を見出した。更に、Na-K ATPase活性が慢性ストレス負荷時に有意に低下することも見出すことが出来た。研究成果の概要（英文）：Repeated stressful events are associated with the onset of major depressive disorder. We previously showed oligodendrocyte-specific activation of the serum/ glucocorticoid-regulated kinase l cascade, increased expression of axon-myelin adhesion molecules, and elaboration of the oligodendrocytic arbor in the corpus callosum of chronically stressed mice. In the current study, we demonstrate that the Na-K ATPase level and membrane potential of oligodendrocytes were reduced by chronic stress exposure. Furthermore, we found that oligodendrocyte primary cultures subjected to chronic stress resulted in changes of protein arginine methylation levels in several RNA-binding proteins. Our these findings suggest that chronic stress disrupts the organization of the nodes of Ranvier by suppressing the Na-K ATPase levels in oligodendrocytes, and that specific white matter abnormalities are closely associated with major depressive disorder onset.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2016～2018;   課題番号：16K07073;   研究分野：神経化学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MIYATA, Shingo"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学東洋医学研究所; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮田, 信吾"},{"creatorName":"ミヤタ, シンゴ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"30484","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70403194","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=70403194"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-12"}],"displaytype":"detail","filename":"16K07073seika.pdf","filesize":[{"value":"307.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16K07073seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/20682/files/16K07073seika.pdf"},"version_id":"71c70619-6548-4cd6-af58-fc2b00cffdc5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"オリゴデンドロサイト","subitem_subject_scheme":"Other"},{"subitem_subject":"タンパクメチル化","subitem_subject_scheme":"Other"},{"subitem_subject":"慢性ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"PI3Kシグナル","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"オリゴデンドロサイト機能異常よるうつ病発症機構へのタンパクメチル化の関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オリゴデンドロサイト機能異常よるうつ病発症機構へのタンパクメチル化の関与","subitem_title_language":"ja"},{"subitem_title":"Molecular mechanisms of the onset of major depression induced by oligodendrocyte dysfunctions","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4550"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"20682","relation_version_is_last":true,"title":["オリゴデンドロサイト機能異常よるうつ病発症機構へのタンパクメチル化の関与"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-20T06:57:53.635758+00:00"}