{"created":"2023-06-20T16:48:40.215824+00:00","id":20679,"links":{},"metadata":{"_buckets":{"deposit":"a35c5b98-fee5-4860-a3f8-640b451eb6a6"},"_deposit":{"created_by":3,"id":"20679","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20679"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00020679","sets":["14:2667:4550"]},"author_link":["43035","3271","43036","43037","43038","43039","43040","43041"],"control_number":"20679","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2018)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05433/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：肺腺癌の3％に存在するMET遺伝子のエクソン14欠失変異を有するBa/F3細胞モデルを樹立して、4種の活性型キナーゼに結合するタイプI、3種の不活性型キナーゼに結合するタイプII,1種のアロステリック阻害するMETチロシンキナーゼ阻害剤(TKI)の感受性を検索した。その結果capmatinibが最も有効であった。次いで、それぞれの薬剤の耐性株を取得した。タイプI耐性ではMET遺伝子のD1228とY1230、タイプII耐性はL1195と F1200に二次的変異が集中していた。一方のタイプの耐性変異は他方のタイプには感受性であることを見出した。研究成果の概要（英文）：We established a Ba/F3 cell model with MET exon 14 skipping mutation that is present about3% of lung adenocarcinoma. Using this model, we tested its sensitivities to 8 MET-tyrosine kinase inhibitors (TKI) including 4 type I TKI that binds to the active form of the kinase, 3 type II that binds to the inactive form and one allosteric inhibitor. As a result, capmatinib was found to be most effective. Next, we derived resistant clones for each drug. D1228 and Y1230 were common sites of the secondary MET mutations for resistant cells against type Ⅰ TKI, whereas L1195 and F1200 were common sites for the type II TKI. In general, the resistance mutation for type I is sensitive to type II, and vice versa.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(B);  研究期間：2016～2018;   課題番号：16H05433;   研究分野：呼吸器外科学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究協力者"},{"subitem_text_value":"研究協力者"},{"subitem_text_value":"研究協力者"},{"subitem_text_value":"研究協力者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Mitsudomi, Tetsuya"},{"subitem_text_language":"en","subitem_text_value":"Nishio, Kazuto"},{"subitem_text_language":"en","subitem_text_value":"Tomida, Shuta"},{"subitem_text_language":"en","subitem_text_value":"Suda, Kenichi"},{"subitem_text_language":"en","subitem_text_value":"Kobayashi, Yoshihisa"},{"subitem_text_language":"en","subitem_text_value":"Koga, Takamasa"},{"subitem_text_language":"en","subitem_text_value":"Fujino, Toshio"},{"subitem_text_language":"en","subitem_text_value":"Nishino, Masaya"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"岡山大学大学病院; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"&EMPTY&"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"光冨, 徹哉"},{"creatorName":"ミツドミ, テツヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43035","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70209807","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=70209807"}]},{"creatorNames":[{"creatorName":"西尾, 和人"},{"creatorName":"ニシオ, カズト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3271","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10208134","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=10208134"}]},{"creatorNames":[{"creatorName":"冨田, 秀太"},{"creatorName":"トミタ, シュウタ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43036","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10372111","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=10372111"}]},{"creatorNames":[{"creatorName":"須田, 健一"},{"creatorName":"スダケンイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43037","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林, 祥久"},{"creatorName":"コバヤシ, ヨシヒサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43038","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古賀, 教将"},{"creatorName":"コガ, タカマサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43039","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤野, 智大"},{"creatorName":"フジノ, トシオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43040","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西野, 将矢"},{"creatorName":"ニシノ, マサヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43041","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-12"}],"displaytype":"detail","filename":"16H05433seika.pdf","filesize":[{"value":"732.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16H05433seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/20679/files/16H05433seika.pdf"},"version_id":"799122f0-7e53-46b2-87c0-b414fbffbadc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肺癌","subitem_subject_scheme":"Other"},{"subitem_subject":"分子標的治療","subitem_subject_scheme":"Other"},{"subitem_subject":"ドライバー癌遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"チロシンキナーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"MET","subitem_subject_scheme":"Other"},{"subitem_subject":"エクソン14スキッピング","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"MET遺伝子のエクソン14欠失変異を有する肺腺癌に対する分子標的治療","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MET遺伝子のエクソン14欠失変異を有する肺腺癌に対する分子標的治療","subitem_title_language":"ja"},{"subitem_title":"Molecular targeted therapy against adenocarcinoma of the lung harboring MET exon 14 skipping mutation","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4550"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"20679","relation_version_is_last":true,"title":["MET遺伝子のエクソン14欠失変異を有する肺腺癌に対する分子標的治療"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-20T06:35:00.056642+00:00"}