{"created":"2023-06-20T16:48:39.792046+00:00","id":20672,"links":{},"metadata":{"_buckets":{"deposit":"c0eb88d4-01ba-4b5a-a7d8-d813e4757839"},"_deposit":{"created_by":3,"id":"20672","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20672"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00020672","sets":["14:2667:4550"]},"author_link":["3878","43019"],"control_number":"20672","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2018)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K14863/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：イネ白葉枯病菌などの病原細菌は、三型分泌装置によりエフェクターと総称される病原性因子を植物細胞内に分泌し、宿主の免疫応答を阻害することが知られている。そのため、エフェクターを分泌する三型分泌装置の形成を阻害する分子標的剤を見出すことができれば、極めて有効な病害防除技術として期待できる。本研究では、三型分泌装置の形成因子の遺伝子発現をモニターするスクリーニング系を構築し、放線菌が生産する代謝化合物のから、三型分泌装置の形成を阻害する分子標的剤を同定した。研究成果の概要（英文）：Bacterial pathogens deliver effector proteins into plant cells by type Ⅲ secretion system. The effectors strongly suppress host immune responses as the virulence factors. Therefore, natural products that can inhibit formation of type Ⅲ secretion system are useful for disease control. To screen such natural products from actinomycete secondary metabolites, we developed a system to monitor expression of the genes involved in formation of type Ⅲ secretion system and found the candidate metabolites that can suppress the type Ⅲ secretion system.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：挑戦的萌芽研究;  研究期間：2016～2018;   課題番号：16K14863;   研究分野：植物保護;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Kawasaki, Tsutomu"},{"subitem_text_language":"en","subitem_text_value":"Yamaguchi, Koji"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学農学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川崎, 努"},{"creatorName":"カワサキ, ツトム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3878","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90283936","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=90283936"}]},{"creatorNames":[{"creatorName":"山口, 公志"},{"creatorName":"ヤマグチ, コウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43019","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-12"}],"displaytype":"detail","filename":"16K14863seika.pdf","filesize":[{"value":"572.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16K14863seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/20672/files/16K14863seika.pdf"},"version_id":"851f183f-84c2-4cfb-b70e-95cab508b8d5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"植物免疫","subitem_subject_scheme":"Other"},{"subitem_subject":"エフェクター","subitem_subject_scheme":"Other"},{"subitem_subject":"三型分泌装置","subitem_subject_scheme":"Other"},{"subitem_subject":"分子標的剤","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"分子標的剤を利用した病原細菌の三型分泌装置形成の制御機構の解明と新規農薬の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"分子標的剤を利用した病原細菌の三型分泌装置形成の制御機構の解明と新規農薬の開発","subitem_title_language":"ja"},{"subitem_title":"Identification of natural products inhibiting formation of type Ⅲ Secretion System of bacterial pathogens","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4550"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"20672","relation_version_is_last":true,"title":["分子標的剤を利用した病原細菌の三型分泌装置形成の制御機構の解明と新規農薬の開発"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-20T01:53:18.012284+00:00"}