{"created":"2023-06-20T16:48:39.105221+00:00","id":20656,"links":{},"metadata":{"_buckets":{"deposit":"30490403-e467-42a3-9701-7ed880fd531a"},"_deposit":{"created_by":3,"id":"20656","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"20656"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00020656","sets":["14:2667:4550"]},"author_link":["3141"],"control_number":"20656","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2018)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18965/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：オキサリプラチン及びパクリタキセル誘発末梢神経障害の発症メカニズムについて解析を行い、腰髄部分（lumber4～6）におけるProteinkinaseC（PKC）活性化に基づくERK経路の活性化が関与することを見出した。また、PKCあるいはMEKを阻害する分子標的薬によりERK経路の抑制を介してオキサリプラチン及びパクリタキセル誘発末梢神経障害を阻害することを明らかにした。以上の結果は、臨床におけるオキサリプラチン及びパクリタキセル誘発末梢神経障害発症時における治療に貢献できる可能性が考えられる。なお、本研究成果は主な発表論文の項に全てまとめてある。研究成果の概要（英文）：I show that oxaliplatin and paclitaxel induces the neuropathy through the activation of PKC/ERK pathway in lumber spinal cords. In addition, PKC and MEK　inhibitor suppressed the oxaliplatin- and paclitzxel-induced neuropathy via PKC/ERK pathways. These findings suggest that PKC and MEK inhibitors are potentially useful for oxaliplatin- and paclitaxel-induced neuropathy. As well, these results are summarized as section of presented paper.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2016～2018;   課題番号：16K18965;   研究分野：薬物治療学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"TSUBAKI, Masanobu"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"椿, 正寛"},{"creatorName":"ツバキ, マサノブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-12"}],"displaytype":"detail","filename":"16K18965seika.pdf","filesize":[{"value":"209.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16K18965seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/20656/files/16K18965seika.pdf"},"version_id":"9e0dd80f-c2a1-4cd3-bd27-9f98f819c2cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"がん化学療法","subitem_subject_scheme":"Other"},{"subitem_subject":"末梢神経障害","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がん化学療法誘発末梢神経障害治療を目指した分子標的薬の応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん化学療法誘発末梢神経障害治療を目指した分子標的薬の応用","subitem_title_language":"ja"},{"subitem_title":"Application of molecular-targeted drugs for treatment of chemotherapy-induced peripheral neuropathy","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4550"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-12"},"publish_date":"2020-03-12","publish_status":"0","recid":"20656","relation_version_is_last":true,"title":["がん化学療法誘発末梢神経障害治療を目指した分子標的薬の応用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-19T07:17:53.632601+00:00"}