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ヒト神経芽細胞腫株 SK-N-SH の神経細胞への分化条件の検討
https://doi.org/10.15100/0002004094
https://doi.org/10.15100/00020040949886c474-209a-42c6-b8fe-06b7983daa8e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063799-20260220-0077.pdf (5.2 MB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||||||||||||||||
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| 公開日 | 2026-04-10 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | ヒト神経芽細胞腫株 SK-N-SH の神経細胞への分化条件の検討 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| その他のタイトル | ||||||||||||||||||||||
| その他のタイトル | Differentiation conditions for human neuroblastoma cell line SK-N-SH into neurons | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 作成者 |
山田, 康枝
× 山田, 康枝
× 富重, 将二
× 元永, 早希恵
× 惠木, 誠一
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| 言語 | ||||||||||||||||||||||
| 言語 | jpn | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | SK-N-SH, Retinoic acid (RA), Nerve growth factor (NGF), Brain-derives neurotrophic factor (BDNF) |
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| 内容記述 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Many aspects of human neural function remain unknown. The reason is the difficulty in conducting straightforward research using human neural cells. Previously, neural cell research relied on primary animal cells or cultured cells, but the results obtained sometimes did not reflect the behavior of cells in the human nervous system. Currently, iPS cells (induced pluripotent stem cells) and ES cells (embryonic stem cells) are differentiated and used for neural function research. However, this requires advanced techniques and extensive equipment, making there a desire for human neural cells obtainable through simpler methods. In this study, we investigated various conditions to identify optimal differentiation conditions for cells usable in human nervous system research by administering retinoic acid (RA), nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) to the human neuroblastoma cell line SK-N-SH. The combination of RA, NGF, and BDNF suggested a closer differentiation toward neural cells. We also demonstrated that the differentiated cells possess human neuronal cell function and indicated their suitability for human neural function research. Further research is needed, but studies using differentiated neural cells are expected to provide important foundational data for drug development targeting neurological disorders and dementia. | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||
| 出版者 | 近畿大学工学部 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||
| ID登録 | ||||||||||||||||||||||
| ID登録 | 10.15100/0002004094 | |||||||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||||
| 収録物識別子 | 2434592X | |||||||||||||||||||||
| 書誌情報 |
ja : 近畿大学工学部研究報告 en : Research reports of the Faculty of Engineering, Kindai University 号 59, p. 77-82, 発行日 2026-02-20 |
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