| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-12-22 |
| タイトル |
|
|
タイトル |
Integrin alpha subunit 2 (ITGA2) enhances cisplatin resistance in osteosarcoma |
|
言語 |
en |
| 作成者 |
Ito, Tomohiko
Oka, Naohiro
Hashimoto, Kazuhiko
Nishimura, Shunji
Akagi, Masao
Goto, Kouji
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Osteosarcoma, chemoresistance, cisplatin-resistant, ITGA2 (integrin alpha subunit 2) |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Osteosarcoma (OS) is the leading cause of cancerrelated deaths in children and adolescents. Current standard treatment strategies, which combine chemotherapy and surgical resection, have significantly improved 5-year survival rates. However, overall survival rate has not dramatically improved over the past few decades. One of the critical factors affecting the overall survival of patients with OS is chemoresistance, either present in the primary tumor or acquired during chemotherapy. In the present study, we established cisplatin-resistant OS cell lines with continuous exposure to cisplatin and observed dysregulated wound healing signaling. Among the genes responsible for wound healing, we focused on ITGA2 (integrin alpha subunit 2), and found that ITGA2 was a critical determinant of cisplatin sensitivity in the OS cells in vivo. Depletion of ITGA2 in cisplatin-resistant OS cells restored cisplatin sensitivity, with a concomitant decrease in previously reported cisplatin resistance signatures, including MYC and oxidative phosphorylation. Conversely, ITGA2 overexpression leads to cisplatin resistance in OS cells. Consistent with these findings, OS patients with high ITGA2 expression showed enhanced gene expression signatures of wound healing and worse prognosis compared to those with low ITGA2 expression. There results suggest that ITGA2 is a potential prognostic marker and therapeutic target in cisplatin-resistant OS. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Kindai University Medical Association |
|
言語 |
en |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| ID登録 |
|
|
ID登録 |
10.15100/0002003779 |
|
ID登録タイプ |
JaLC |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
24327166 |
| 書誌情報 |
en : ACTA MEDICA KINDAI UNIVERSITY
巻 50,
号 2,
p. 21-30,
発行日 2025-12
|
AA0050842X-20251200-0021.pdf (2.0 MB)
