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Modification by steroids of pulmonary oedema and prostaglandin E2 pharmacokinetics induced by endotoxin in rats
https://kindai.repo.nii.ac.jp/records/2003710
https://kindai.repo.nii.ac.jp/records/20037102529a4ae-4c28-4024-b0e9-65aefe00db7d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19890600-0129.pdf (837.7 KB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-09-22 | |||||||
| タイトル | ||||||||
| タイトル | Modification by steroids of pulmonary oedema and prostaglandin E2 pharmacokinetics induced by endotoxin in rats | |||||||
| 言語 | en | |||||||
| 作成者 |
Izumi, Takafumi
× Izumi, Takafumi
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | steroids, endotoxin, rat lung, prostaglandin metabolism, lung oedema | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | A single intraperitoneal injection of bacterial endotoxin into rats (3.5 mg・kg-1) caused lung injury assessed as changes in lung dry : wet weight ratio and leukopaenia over the subsequent 28 h. This treatment also slowed the efflux of 14C from [14C]-prostaglandin E2 in isolated perfused lungs over the same period. These effects of endotoxin were reversed by methylprednisolone (30 mg・kg-1), given 30 min after the endotoxin. Another synthetic corticosteroid, budesonide, given at 1.2 mg・kg-1, 1 h before endotoxin partially prevented the lung injury and leukopaenia but did not affect the increased t1/2 of prostaglandin E2 nor its survival. The reversal by methylprednisolone of both the physical signs of lung injury and the changes in prostaglandin E2 pharmacokinetics caused by endotoxin could serve as an index of acute lung injury following sepsis. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 129 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 142 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 14, 号 1, p. 129-142, 発行日 1989-06 |
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