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Characteristics of malignant hypertensive SHRSP (M-SHRSP) and normotensive WKY crossbred offspring (2) : the effects of dietary salt ingestion upon crossbred offspring blood pressures and stroke lesion rates
https://kindai.repo.nii.ac.jp/records/2003709
https://kindai.repo.nii.ac.jp/records/200370945aaa0f5-e05c-4ee9-9f3e-0a0f71ff4410
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19890600-0117.pdf (837.4 KB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-09-22 | |||||||
| タイトル | ||||||||
| タイトル | Characteristics of malignant hypertensive SHRSP (M-SHRSP) and normotensive WKY crossbred offspring (2) : the effects of dietary salt ingestion upon crossbred offspring blood pressures and stroke lesion rates | |||||||
| 言語 | en | |||||||
| 作成者 |
Yamamoto, Kazuo
× Yamamoto, Kazuo
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | M-SHRSP, WKY, crossbred M-SHRSP hybrids, NaCl, blood pressure, stroke lesion | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | This study is on how dietary salt ingestion affected blood pressures and stroke lesion rates of rats taken from colonies of very severely hypertensive M-SHRSP, normotensive WKY, and three strains of M-SHRSP and WKY crossbred offspring evidencing intermediate levels of hypertension, i.e., WT-T F4 (severe), WT-T F1 (moderate), and W-WT F1 (mild). All of the strains were divided into control and experimental groups, and the latter were given 1% NaCl in drinking water. Blood pressures for the experimental, dietary salt groups were higher than those for the controls. Also, the more severe the hypertension the more quickly and rapidly were these increases observed. NaCl administration, however, appeared to have only a limited effect upon the blood pressures of mildly hypertensive and normotensive rats. Pathological changes such as cerebral hemorrhages, resulting from the ingestion of 1% NaCl, were more commonly observed among M-SHRSP and WT-T F4 while cerebral softenings were more often seen among WT-T F1 compared to those in the respective control. No cerebral lesions were observed in both the experimental and control group W-WT F1 or WKY. Administration of 1% NaCl did significantly shorten the life spans of all the experimental groups. These results indicate that the more severe the level of hypertension, the more potent are the hypertension-aggravating effects of dietary salt. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 117 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 128 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 14, 号 1, p. 117-128, 発行日 1989-06 |
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