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A light and electron microscopical study on transvascular transport of brain edema fluid around cryogenic lesion in rat brain
https://kindai.repo.nii.ac.jp/records/2003702
https://kindai.repo.nii.ac.jp/records/2003702d4e164e3-cdbf-4c09-9861-549cf9624566
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19890600-0001.pdf (2.4 MB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-09-22 | |||||||
| タイトル | ||||||||
| タイトル | A light and electron microscopical study on transvascular transport of brain edema fluid around cryogenic lesion in rat brain | |||||||
| 言語 | en | |||||||
| 作成者 |
Maekura, Shunji
× Maekura, Shunji
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | resolution, transvascular transport, brain edema, cold injury, peroxidase, microelectrophoresis | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Experimental cerebral edema was produced in rats by cold injury method in the fronto-parietal cortex, and the dynamics of cerebral interstitial fluid and the resolution of brain edema fluid around the lesion were then examined in the rat brain. Horseradish peroxidase (HRP) was injected into the fronto-parietal cortex near the cold lesion by microelectrophoresis as the tracer for interstitial fluid dynamics. In the control group, there was a regular pattern of tracer distribution. The tracer spread in a round shape at first. The area where the tracer could be seen macroscopically became smaller as time passed. Forty eight hours after the injection, the tracer was macroscopically seen only near the injection site, but could be still seen in the neuronal cytoplasms, nerve fibers and vascular walls. In the injury group, the "dense tracer distribution around the focus" was observed in addition to the regular pattern of tracer distribution as the control group. This phenomenon was most remarkable 3 days after the injury procedure. In the models of this stage, the areas around the cold lesion were observed electron microscopically. Reaction product was seen in many endothelial vesicles. Some of those vesicles seemed to be opening at the abluminal endothelial surface of the blood vessels. The perivascular structure was considerably well preserved in this region. In the comparative experiment, the animals with intravenous HRP administration 3 days after the cold injury procedure was revealed extravasation of the tracer into the injury core. Therefore, it is considered that the edema fluid extravasated in the injury core and was absorbed transvascularly around the focus at this period. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 1 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 11 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 14, 号 1, p. 1-11, 発行日 1989-06 |
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