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Energy metabolism in frog denervated skeletal muscle during contracture studied with 31P nuclear magnetic resonance
https://kindai.repo.nii.ac.jp/records/2003695
https://kindai.repo.nii.ac.jp/records/2003695cf82a2e8-27cf-4e39-9e6d-82f9c7441c10
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19891200-0275.pdf (565.2 KB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-09-22 | |||||||
| タイトル | ||||||||
| タイトル | Energy metabolism in frog denervated skeletal muscle during contracture studied with 31P nuclear magnetic resonance | |||||||
| 言語 | en | |||||||
| 作成者 |
Hamaguchi, Masamitsu
× Hamaguchi, Masamitsu
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | nuclear magnetic resonance, denervation, energy metabolism, viability, potassium contracture, caffeine contracture | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Unilateral transection of the sciatic nerve in the frog resulted in a decrease in the relative wet weight of the sartorius muscle about 4 weeks postoperatively in contrast to the contralateral side. Energy metabolism was compared between the denervated and the contralateral innervated muscles at rest and during contracture with 31P nuclear magnetic resonance (NMR). The denervated muscle showed a decrease in the relative concentration of phosphocreatine (PCr) to β-adenosine triphosphate (β-ATP) at rest, which started about 4 weeks after denervation and this state indicated a decrease in the energy store. Sartorius muscles, 3-6 weeks after denervation, showing a wet weight decrease of 95-75% were perfused with a potassium solution to induce potassium contracture for determination of serial changes in the PCr/β-ATP ratio. The contraction-associated decrease in PCr/β-ATP and an increase in inorganic phosphate (Pi)/β-ATP of the denervated muscle were less marked than those in the control. In caffeine contractures, the denervated and innervated muscles showed similar serial changes in the PCr/β-ATP and Pi/β-ATP ratios. After a lapse of 1 week or more following denervation, the muscular tension induced by potassium contracture decreased, but no decrease was observed in the caffeine contracture, because of the inhibition of excitation-contraction coupling. It is suggested that phosphate metabolism of the denervated muscles during contracture is parallel to the change of tension, showing little difference from the innervated muscles in the early stage of atrophy. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 275 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 283 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 14, 号 2, p. 275-283, 発行日 1989-12 |
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