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Characteristics of hypertensive hypercholesterolemic rats (Hyper T-C rat), a new strain
https://kindai.repo.nii.ac.jp/records/2003691
https://kindai.repo.nii.ac.jp/records/2003691752033ec-15d5-454a-a879-be2521ea0b68
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19891200-0229.pdf (2.4 MB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-09-22 | |||||||
| タイトル | ||||||||
| タイトル | Characteristics of hypertensive hypercholesterolemic rats (Hyper T-C rat), a new strain | |||||||
| 言語 | en | |||||||
| 作成者 |
Higashizawa, Tomoaki
× Higashizawa, Tomoaki
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | hypertension, hypercholesterolemia, arteriosclerosis, nephrotic syndrome, M-SHRSP, SHC hybrid | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Using hybrid offspring developed through crossbreeding severely spontaneously hypertensive rats (M-SHRSP) with spontaneously hypercholesterolemic rats (SHC), it was possible to establish a colony of Hyper T-C rats exhibiting both hypertension and hypercholesterolemia. The present paper relates the development and characteristics of this new strain from generations F1 through F20. At 20 weeks of age, male Hyper T-C had blood pressures around 230 mmHg and plasma total cholesterol levels of approximately 400 mg/dl, for females at 25 weeks of age, the figures were about 230 mmHg and 500 mg/dl, respectively. Also, at this age, the plasma total cholesterol/high density lipoprotein (HDL) cholesterol ratio was relative low while that of the low density lipoprotein (LDL) cholesterol was noticeable high. Just as with SHC, Hyper T-C also manifested protein excretion in the urine, hypoalbuminemia and, under both light and electron microscopes, showed abnormal permeable lesions in the renal glomeruli capillary walls, findings similar to human nephrotic syndrome symptoms. It is thought that such increases in plasma total cholesterol levels are caused by these renal disorders. In addition to the above, Hyper T-C rats also showed evidence of typical hypertensive changes in a number of organs. For example, hypertensive changes in the afferent arterioles and resulting ischemic changes in the capillary basement membrane of the glomeruli were found in the kidneys. In particular, similar to human arteriosclerosis, there were arteriosclerotic changes found in heart and kidney muscular arteries with an outer diameter of 150 to 800 μm. The above findings show that these Hyper T-C rats have an excellent potential as an animal model for arteriosclerosis. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 229 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 247 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 14, 号 2, p. 229-247, 発行日 1989-12 |
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