| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-09-22 |
| タイトル |
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|
タイトル |
Establishment of an inbred strain of hypertensive hypercholesterolemic rats (Hyper T-C rat) |
|
言語 |
en |
| 作成者 |
Okamoto, Kozo
Higashizawa, Tomoaki
Miyake, Hideo
Ito, Hiroyuki
Suzuki, Tsuneyuki
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
hypertension, hypercholesterolemia, SHR hybrid, stroke |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
By successive selective brother-sister breeding of crossbred hybrid male TC-C and female TC, both developed by crossing severely hypertensive rats (M-SHRSP) with spontaneously hypercholesterolemic rats (SHC), a colony of hypertensive, hypercholesterolemic rats (Hyper T-C rats) was obtained and an inbred strain established. Males of this new strain show blood pressures of around 230 mmHg and plasma total cholesterol levels of 400-500 mg/dl at 20 weeks of age. Females show blood pressures of around 230 mmHg and plasma total cholesterol levels of 500 mg/dl at 25 weeks of age. The incidence of cerebral stroke lesions in generation F16-F20 was 47% for males and 57% for females. Life spans were 151 days and 186 days, respectively. Vascular changes such as angionecrosis and/or hyaline degeneration in these Hyper T-C rats develop in the brain and kidneys after blood pressures have continued to be above 220 mmHg for about 2 weeks and in the heart, thyroid gland, adrenal glands, and testes after such levels have been maintained for an additional 1 to 2 weeks. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 開始ページ |
|
|
開始ページ |
211 |
| 終了ページ |
|
|
終了ページ |
227 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 14,
号 2,
p. 211-227,
発行日 1989-12
|
AA0050842X-19891200-0211.pdf (2.3 MB)
