| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-09-22 |
| タイトル |
|
|
タイトル |
Clinical differences between hypoplastic and normocellular or hyperplastic myelodysplastic syndrome |
|
言語 |
en |
| 作成者 |
Ashida, Takashi
Hazu, Shizuka
Ishikawa, Hiroyuki
Urase, Fumiaki
Tsubaki, Kazuo
Irimajiri, Kiyohiro
Horiuchi, Atsushi
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Myelodysplastic syndrome, hypoplasia, dysplasia, chromosome abnormality |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
We studied a type of myelodysplastic syndrome (MDS) characterized by hypoplastic bone marrow. Seven patients studied had hypoplasia of bone marrow. Twenty-one patients had normocellular or hypercellular marrow. Comparisons of clinical features, hematological findings, chromosome analysis, incidence of progression to acute leukemia and survival were made betweeen hypoplastic and normocellular or hyperplastic MDS. The median age of patients was 74 years in the hypoplastic group and 59 years in the normocellular or hyperplastic group. According to the French-American-British (FAB) classification, the hypoplastic disease group included on patient with refractory anemia (RA), five with refractory anemia with excess of blast (RAEB), and one with RAEB in transformation (RAEB-t). Those with normocellular or hypercellular marrow included seven with RA, two with refractory anemia with ringed sideroblasts (RARS), nine with RAEB and three with RAEB-t. Patients with hypoplastic MDS had severe leukopenia and lower hemoglobin levels than did those in the other group. Five patients with hypoplastic MDS had chromosome of bone marrow analyzed, and three (60%) had abnormalities. Among those with normocellular or hyperplastic bone marrow, 17 had analyses, seven (41.2%) of whom had abnormal results. Four patients (57.1%) from the hypoplastic group and four (19.0%) from the normocellular of hyperplastic group suffered transformation to acute leukemia. Mean length of time from diagnosis to transformation to overt leukemia was 29 months for patients in the hypoplastic group, and 11 months for patients in the normocellular or hyperplastic group. Median survival was 25 months for patients in the hypoplastic group, and 9 months for patients in the normocellular or hyperplastic group. Therefore, hypoplastic MDS appears to be a clinicopathological entity separate from normo- or hyperplastic MDS, and is characterized by marrow hypoplasia, severe leukeopnia and anemia and long survival. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 開始ページ |
|
|
開始ページ |
119 |
| 終了ページ |
|
|
終了ページ |
125 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 15,
号 2,
p. 119-125,
発行日 1990-12
|
AA0050842X-19901200-0119.pdf (427.3 KB)
