| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-09-22 |
| タイトル |
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|
タイトル |
The serum half-life of exogenous human recombinant interleukin-2 in a dog model |
|
言語 |
en |
| 作成者 |
Ohnishi, Hiroaki
Okuno, Kiyotaka
Koh, Kenzo
Yasutomi, Masayuki
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
interleukin-2, half-life, clearance, kidney, dog |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
The clearance of exogenous recombinant human interleukin-2 (hIL-2) was characterized in a dog model. The titer of recombinant hIL-2 activity was measured using a radioimmunoassay. Intravenously injected hIL-2 disappeared from the blood circulation rapidly with a serum half life of 4.5±0.1 minutes (mean±SD). The reason for the short half life of i.v. injected hIL-2 was studied. To determine whether hIL-2 has been bound or consumed by peripheral blood lymphocyte (PBL) or serum, the IL-2 titer that has been cultured with PBL or serum in vitro was measured. No inhibitable effect of either lymphocyte and serum on the initial titer of cultured IL-2 could be detected. Interestingly, a surgical bilateral renal block on the dog greatly extended the serum half life of hIL-2 to 33.9±2.7 minutes. Administered hIL-2 was not excreted in a detectable form in the urine either the control or experimental group. These findings demonstrated that the kidney is the major organ to metabolize IL-2, possibly renal tubular catabolism. |
|
言語 |
en |
| 出版者 |
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|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 開始ページ |
|
|
開始ページ |
97 |
| 終了ページ |
|
|
終了ページ |
103 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 15,
号 2,
p. 97-103,
発行日 1990-12
|
AA0050842X-19901200-0097.pdf (497.9 KB)
