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Rat behaviors in artificial septal syndrome
https://kindai.repo.nii.ac.jp/records/2003676
https://kindai.repo.nii.ac.jp/records/2003676bd67c48e-2f89-4551-9bb7-645ce0193518
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19901200-0105.pdf (1.3 MB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-09-22 | |||||||
| タイトル | ||||||||
| タイトル | Rat behaviors in artificial septal syndrome | |||||||
| 言語 | en | |||||||
| 作成者 |
Hashimoto, Atsutaka
× Hashimoto, Atsutaka
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | rat, septal nucleus destruction, biphasic behavioral change | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | In 1953, Nauta and Brady described characteristic behavioral changes following septal nucleus destruction in rats which had never been seen in a normal physiological state. The pathognomonic symptoms are called rat septal syndrome, and many reports have been described since then. The cardinal symptoms of this syndrome is hyper-emotionality associated with extreme excitement. In this report, we used rats as subject animals just like Nauta, Brady and other succeeding researchers did. Six non-brain-injured normal control rats, six rats of electrical unilateral destruction of the septal nucleus, six unilaterally prefrontal cortex destructed rats were used as the subject animals in this study. Six outside stimuli in the visual, auditory and tactile sensorial modes were administered to the subject animals, and their reactive behavioral changes were observed. Behavioral ratings were evaluated in five degrees from 0 to 4 points. Zero indicated no reaction and 5 points meant a very severe reaction. The results were as follows: the six septum destroyed rats showed typical septal syndrome, with symptoms in total correspondence with those reported by Nauta and Brady. On the other hand, the six prefrontally destructed rats and the six non-brain-injured normal control rats did not indicate the symptoms at all. These septal syndrome symptoms that the author found settled within about one month. The duration of this recovery period is average according to previous reports. In the author's observation, near the mid-point in the course of recovery, the rats displayed over-sedated or depressed behavior. About 14 days after the onset of septal syndrome, the rats seemed much hypoactive than normal state. No descriptions were found about such interesting behavioral changes in any previous reports. The underlying mechanisms for such a biphasic behavioral change to normalization have still not been revealed. From clinical stand point of view, general course of catatonic schizophrenia proposed by Karlbaum, or periodic catatonia proposed by Gjessing showed similar to some extent to rat septal syndrome, though it is a jump of logic to compare human behavior to rat behavior immediately. In this respect, rat septal syndrome might provide some insights to a certain area of the clinical neuropsychiatry. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 105 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 117 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 15, 号 2, p. 105-117, 発行日 1990-12 |
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