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Influence of whole body rinse-out with FC-43 perfluorocarbon emulsion on experimental endotoxin shock
https://kindai.repo.nii.ac.jp/records/2003332
https://kindai.repo.nii.ac.jp/records/2003332f1da95ae-cbd2-4b31-bbf7-ec9fd132cc7b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19920600-0001.pdf (1.1 MB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-08-05 | |||||||
| タイトル | ||||||||
| タイトル | Influence of whole body rinse-out with FC-43 perfluorocarbon emulsion on experimental endotoxin shock | |||||||
| 言語 | en | |||||||
| 作成者 |
Voynikov, I. Tencho
× Voynikov, I. Tencho
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | perfluorocarbons, blood substitutes, exchange-transfusion, endotoxin, blood parameters, survival rate | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | In order to examine the effects of normothermic whole body rinse-out (NWBRO) with FC-43 perfluorocarbon emulsion on the course and outcome of entotoxin shock, a number of experiments with male Wistar rats were carried out. These animals, conscious and unrestrained, were infused over 10 min with 60 mg/kg Escherichia coil endotoxin (LD100) and observed for 6 hours. The rats developed hypotension, plasma extravasation, metabolic acidosis, hyperlactemia, hypoglycemia, elevated oxygen extraction from blood, leukopenia, thrombocytopenia, increase in serum GOT and GPT, extensive hemorrhages in the small intestine; they died 4.9±0.6 hours potinfusion. Another group of rats was subjected to blood substitution with FC-43 emulsion (artificial blood) 30 min after endotoxin application, until hematocrit dropped to less than 3%, after which 6-9 ml of donor blood was exchange-transfused with the emultion. Although NWBRO caused hypotension, transitory rises in blood lactate and GOT levels, and a fall in arterial oxygen content due to the lower hemoglobin (erythrocyte) level, more importantly: it resulted in 98% endotoxin clearance; improved blood alkaline reserves; preserved blood glucose; trimmed elevated GPT and GOT levels; benefited leukopenia and restored platelet number; normalized arterial-mixed venous oxygen gradient and O2-extraction from the blood (which implies preserved blood circulation status); attenuated hemorrhage and epithelial necrosis in the small intestine; and increased the survival rate to 100% at 6 h, 46% at 12 h, and 35% at 24 h. Survival rates were studied in additional groups of endotoxic rats: those subjected to FC-43 blood substitution only had the worst survival rate; administration of 30 mg/kg methylprednisolone alone, or in combination with NWBRO did not have any significant effect; while exchange-transfusion with 8-10 ml donor blood alone resulted in the highest survival rate. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 1 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 16 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 17, 号 1, p. 1-16, 発行日 1992-06 |
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