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Changes in unit activities of VPL thalamic neurons after middle cerebral artery occlusion in rats
https://kindai.repo.nii.ac.jp/records/2003323
https://kindai.repo.nii.ac.jp/records/200332382ec7c24-075d-4b5f-999d-faee95e87fd9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19911100-0103.pdf (865.1 KB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-08-06 | |||||||
| タイトル | ||||||||
| タイトル | Changes in unit activities of VPL thalamic neurons after middle cerebral artery occlusion in rats | |||||||
| 言語 | en | |||||||
| 作成者 |
Tokuno, Tatsuya
× Tokuno, Tatsuya
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | middle cerebral artery, ischemia, unit activity, VPL, somatosensory evoked potential | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Evoked responses in VPL thalamic neurons following infarction of the somatosensory cortex were examined in anesthetized rats. The cortical infarction was produced by middle cerebral artery occlusion (MCAO). One, 4 and 7 days after MCAO, VPL neuron activities evoked by electrical stimulation of the contralateral forelimb were recorded with 2M-NaCl-filled glass microelectrodes. The electrical stimulus was applied 25 times. The frequency of repetition was gradually increased from 1 to 50 Hz. At each frequency the average number of spikes in response to each group of 25 stimuli (firing probability) was calculated. The infarcted area and the degenerative changes in the thalamus were evaluated after staining with 2,3,5-triphenyltetrazolium chloride (TTC). The evoked unit activities could be detected at all times studied. Firing probability of the VPL units decreased with increased stimulation frequency. In the control group, the reduction in the firing probability was mild, while in the MCAO groups the reduction became more prominent especially 1 day after MCAO. One day after MCAO all the units were less responsive to somatosensory inputs, and by the fourth day after MCAO the responsiveness of several neurons had recovered to levels close to those of the control preparations. In the TTC staining study, reduction of stainability was observed in the ipsilateral thalamus 4 days after MCAO. The present study demonstrates the existence of functional neurons even 7 days after MCAO, and shows that somatosensory cortical and/or subcortical infarction depresses somatosensory transmission in VPL neurons. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 103 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 115 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 16, 号 2, p. 103-115, 発行日 1991-11 |
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