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Early postnatal development and learning ability of the rat offspring prenatally exposed to methylazoxymethanol acetate
https://kindai.repo.nii.ac.jp/records/2003320
https://kindai.repo.nii.ac.jp/records/2003320e662baa7-ef1f-4d7f-9e6c-d7a89a131513
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19910600-0051.pdf (382.1 KB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||||
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| 公開日 | 2025-08-06 | |||||||||
| タイトル | ||||||||||
| タイトル | Early postnatal development and learning ability of the rat offspring prenatally exposed to methylazoxymethanol acetate | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Yamamoto, Yoshitame
× Yamamoto, Yoshitame
× Tanimura, Takashi
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| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | methylazoxymethanol acetate, reflex function, motor development, early postnatal behavioral development, learning behavior | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Methylazoxymethanol acetate (MAM) was injected intraperitoneally into female Crj: CD rats on day 13 of pregnancy at a dose of 30 mg/kg. The reflex development, motor coordination, and motor capacity of their offspring were assessed from the early postnatal period until weaning. In addition, the learning behavior was investigated after weaning. Rats exposed to MAM in utero showed a significant delay in the cliff avoidance reflex and negative geotaxis. With respect to motor coordination and motor capacity, rats exposed to MAM showed significant delays in achieving control of the direction and angle of the body in swimming, as well as in the use of all four limbs. In post-weaning learning behavior, the time required to complete a T-maze was significantly prolonged and the number of errors significantly increased in the MAM offspring. Pre-weaning disorders detected in the neurological maturation of rats exposed to MAM in utero provide information which could be of value in predicting behavioral impairments in mature animals. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||
| 言語 | en | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03866092 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 51 | |||||||||
| 終了ページ | ||||||||||
| 終了ページ | 56 | |||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 16, 号 1, p. 51-56, 発行日 1991-06 |
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