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アイテム
An experimental study of peripheral nerve regeneration by utilizing a collagen film comparison with a silicone tubing method
https://kindai.repo.nii.ac.jp/records/2003317
https://kindai.repo.nii.ac.jp/records/2003317cd18e884-8683-464b-9e6a-cc3cf0329a3d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19910600-0023.pdf (1.9 MB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-08-06 | |||||||
| タイトル | ||||||||
| タイトル | An experimental study of peripheral nerve regeneration by utilizing a collagen film comparison with a silicone tubing method | |||||||
| 言語 | en | |||||||
| 作成者 |
Hosokawa, Kouichi
× Hosokawa, Kouichi
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | entubulation, regeneration, maturation of axon, motor functional recovery, collagen film, silicone tube | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | The author examined peripheral nerve regeneration in 64 rats in which both sciatic nerves had been severed and the nerve on one side had been treated with collagen film wrapping and that on the other with silicone tubing. Morphological and electrophysiological results for silicone tubing and collagen film wrapping methods were compared. The gap between the proximal and distal stumps of the severed nerve was maintained at a distance of 10 mm. Chronological observation of surviving rats was performed at 1, 2, 3, 4, 6, 9, 12 and 15 months after operation. Morphometric analysis of the number of axons, mean axon diameter, percent large axons, and myelin ratio at the mid position within the gap of the regenerating nerve trunk was performed. Electrophysiological examination and toe-spreading tests were performed to evaluate the recovery of motor function. Severed nerves could be bridged in both experimental models, even though the nerve defect was 10mm in length. Recovery from conductive failure on the wrapping side was found in about 90% of experimental animals, and in about 65% on the tubing side. Final number of axons was approximately 1,550 on the wrapping side and 1,800 on the tubing side. Mean axon diameter was about 4 μm on the wrapping side and about 3.2 μm on the tubing side. Mean conduction velocity (MCV) recovered to about 35 m/sec on the wrapping side and to about 25 m/sec on the tubing side. Remarkable differences in functional recovery and maturation between the tubing and wrapping sides became significant 6 months after operation. Nerve repair with axon maturation and restored motor function was complete within 15 months after operation. Collagen film is an excellent nerve conduit material superior to silicone tubing in inducing recovery of motor function and especially in inducing the maturation of the sprouted nerve axons. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 23 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 38 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 16, 号 1, p. 23-38, 発行日 1991-06 |
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