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アイテム
Responses to vasocontractile agents in caudal artery and aorta from stroke-prone SHR, especially in relation to aging
https://kindai.repo.nii.ac.jp/records/2003223
https://kindai.repo.nii.ac.jp/records/2003223b88ade04-2b19-47e9-940b-4ef9c0c06f60
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19931100-0097.pdf (621.6 KB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-07-17 | |||||||
| タイトル | ||||||||
| タイトル | Responses to vasocontractile agents in caudal artery and aorta from stroke-prone SHR, especially in relation to aging | |||||||
| 言語 | en | |||||||
| 作成者 |
Yamanishi, Yasuko
× Yamanishi, Yasuko
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | stroke-prone SHR, WKY, caudal artery, aorta, alpha-receptor stimulating drugs, serotonin, angiotensin II, K+ | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | The present study investigated the responses of the proximal part of the caudal artery from stoke-prone SHR to vasocontractile agents, including alpha-1 receptor stimulating agents with respect to aging and compared them with those of WKY. The responses to the alpha-receptor stimulating agents were also studied in the aortas from stroke-prone SHR and WKY. In the caudal artery, the responses to the receptor-stimulating agents, noradrenaline (Nad), phenylephrine (PhE), methoxamine (Meth), angiotensin II (Ang) and serotonin for 1.5 month-old storke-prone SHR were not different from those for the age-matched WKY, but the responses to these agents with the exception of Nad were larger in the 3 month-old stroke-prone SHR than in the age-matched WKY. The responses to Nad, PhE, Meth and Ang for the 6 month-old stroke-prone SHR were smaller than those for the age-matched WKY, but these to serotonin were larger in stroke-prone SHR than in WKY. The responses to K+ were larger in stroke-prone SHR at 1.5, 3 and 6 months of age than in the age-matched WKY. The pD2 values of Nad, PhE and Meth obtained from stroke-prone SHR were not different from those in WKY at any age tested. In the aorta, the responses to Nad, PhE and Meth in stroke-prone SHR at 1.5, 3 and 6 month of age were larger than those at the age-matched WKY, but the responses to these agents in 6 month-old stroke-prone SHR were not different from those for the age-matched WKY. The pD2 values of Nad, PhE and Meth in stroke-prone SHR at 1.5, 3 and 6 months of age were not different from those for the age-matched WKY. These results suggest that the contractile responses to receptor-mediated drugs in the blood vessels of stroke-prone SHR are affected by aging or blood pressure, but the degree differs according to the kind of blood vessel or the kind of drugs. However, these results also suggest that the affinity of sympathetic alpha-receptors is not affected by blood pressure in the caudal artery and aorta. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 97 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 107 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 18, 号 2, p. 97-107, 発行日 1993-11 |
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