WEKO3
アイテム
Oxygen radical formation by splenic macrophages in non-obese diabetic (NOD) mice
https://kindai.repo.nii.ac.jp/records/2003216
https://kindai.repo.nii.ac.jp/records/20032169837fe78-8a11-415c-83ca-f778e30c9173
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19930600-0021.pdf (510.6 KB)
|
|
| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-07-17 | |||||||||
| タイトル | ||||||||||
| タイトル | Oxygen radical formation by splenic macrophages in non-obese diabetic (NOD) mice | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Imamura, Minoru
× Imamura, Minoru
× Aoki, Norihiko
|
|||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | Oxygen radicals, NOD mice, Macrophage | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | In an attempt to determine the roles of oxygen radicals in the destruction of pancreatic β cells and in the development of diabetes, oxygen radical formation was measured in splenic macrophages from non-obsee diabetic (NOD) mice which had been treated with cyclophosphamide (CY). Oxygen radical formation in macrophages due to CY was enhanced both in NOD and ICR mice with a higher response in NOD than in ICR. Even in animals not receiving CY, NOD mice showed a significantly high level of oxygen radical formation in splenic macrophages as compared with the control ICR mice. CY enhanced the oxygen radical formation in NOD mice which reached a peak at 14 days after CY treatment after which it decreased. This enhancement by CY treatment was in part suppressed by silica, which is selectively toxic for macrophages. Mac-1 (CD11b/CD18) antigen on macrophages was augmented by CY, which was also suppressed by silica. Thus, the enhancement of oxygen radical formation and Mac-1 antigen in macrophages seems to contribute to the pathogenesis of CY-induced diabetes in NOD mice besides well-established roles by lymphoid cells. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||
| 言語 | en | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03866092 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 21 | |||||||||
| 終了ページ | ||||||||||
| 終了ページ | 28 | |||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 18, 号 1, p. 21-28, 発行日 1993-06 |
|||||||||
