| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-07-15 |
| タイトル |
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|
タイトル |
Influence of Nivalin P on the training and memorizing processes in rats |
|
言語 |
en |
| 作成者 |
Markov, Marko
Danchev, Nikolai
Uzunov, Petko
Higashino, Hideaki
Suzuki, Aritomo
|
| 言語 |
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|
言語 |
eng |
| キーワード |
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|
主題 |
Nivalin P, Alzheimer's disease, training processes, memory traces |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
The effects of Nivalin P-in a combination ratio of 1:1 by two compounds Galan-thamine (Nivalin) and 4-aminopyridine (Pymadin) on the total latency time, conditional, unconditional and inadequate reactions in rats were studied. Nivalin is a cholinesterase inhibitor which enhances the cholinergic system by blocking the degradation of the mediator acetylcholine (ACh) in the synapse. Pymadin is a stimulator of the presynaptic release of ACh and its synthesis. The experiments were performed with male Wistar rats weighing 150-170 g which were divided into 4 groups: control and three experimental groups treated orally with Nivalin P in a dose of 6.6 mg/kg (= 1/5 LD50), 3.3 mg/kg (= 1/10 LD50) and 1.65 mg/kg (= 1/20 LD50), respectively. A two-way active avoidance method in a "shuttle box" and the method of Valcelli, L. were used for examination of the memory traces. Nivalin P applied in a dose 1/20 of the LD50 orally in rats facilitates the training of rats and improves the memory capabilities decreasing the number of inadequate replies. These findings indicate that Nivalin P in low doses induces the enhancement of the cholinergic activity by pharmacological intervention within the synapse. Apparently, the role of combination therapies, including inhibitors of the breakdown of ACh with facilitators of neuronal calcium uptake appears logical and might be useful in the treatment of Alzheimer's disease. |
|
言語 |
en |
| 出版者 |
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|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
03866092 |
| 開始ページ |
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|
開始ページ |
119 |
| 終了ページ |
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|
終了ページ |
126 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 19,
号 2,
p. 119-126,
発行日 1994-11
|
AA0050842X-19941100-0119.pdf (509.2 KB)
