| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-07-15 |
| タイトル |
|
|
タイトル |
Pharmacological and toxicological study of newly synthesized 1,3-dimethylxanthine derivatives |
|
言語 |
en |
| 作成者 |
Markov, Marko
Danchev, Nikolai
Ivanov, Dimitar
Panova, Jordanka
Higashino, Hideaki
Suzuki, Aritomo
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
compound 61, compound 62, aminophylline, bronchodilatory effect, tracheal relaxant action, cyclic AMP-PDE activity |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Two originally 7-basic substituted theophylline derivatives from theophylline sodium salt, dichloroalkane and N-methyl-N-cyclohexyl amine were synthesized and their pharmacological activities in guinea pigs and rats were studied. The acute toxicity (LD50) of the compounds was determined in mice and rats by the method of Litchfield and Wilcoxon, using a personal Pravetz 8M computer. A comparative pharmacological study on the in vivo bronchodilatory effects and in vitro tracheal relaxant action of the synthesized compounds with aminophylline was performed in guinea pigs. The inhibition of cyclic AMP-phosphodiesterase (PDE) in the heart and lungs of rats by these compounds was compared to that by theophylline. The newly synthesized compounds had in vivo and in vitro bronchodilatory and diuretic activities, and exerted a marked inhibitory effect on the cyclic AMP-PDE in lung homogenates of rats. These findings indicate that the substitutions with a shorter carbonic chain at the 7-position could improve the bronchodilatory effect of methylxanthines. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 開始ページ |
|
|
開始ページ |
99 |
| 終了ページ |
|
|
終了ページ |
103 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 19,
号 2,
p. 99-103,
発行日 1994-11
|
AA0050842X-19941100-0099.pdf (312.7 KB)
