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Prolonged psychiatric symptoms induced by recombinant alpha-2a interferon in a patient with chronic hepatitis C
https://kindai.repo.nii.ac.jp/records/2003199
https://kindai.repo.nii.ac.jp/records/200319949249626-d6da-4790-ba33-5227ebfbab4a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19940600-0041.pdf (440.6 KB)
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| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||||||||||||||||
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| 公開日 | 2025-07-11 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Prolonged psychiatric symptoms induced by recombinant alpha-2a interferon in a patient with chronic hepatitis C | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 作成者 |
Iida, Masashi
× Iida, Masashi
× Fukuya, Masato
× Nishikawa, Mizuho
× Ikenaga, Masaichi
× Hanada, Masanori
× Kurumi, Yoshiaki
× Nakagawa, Hirotaka
× Adachi, Yukihiko
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| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | alpha-2a interferon, encephalopathy, prolonged mental symptoms, multiple lacunae, agitation, suicidal ideas | |||||||||||||||||||||
| 内容記述 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | While receiving recombinant alpha-2a interferon (INF) therapy (total dose, 78×10⁶ IU) for chronic active hepatitis C, a 56-year-old male exhibited neuropsychiatric manifestations of mild encephalopathy consisting of disorientation regarding time, impaired recent memory and word-finding ability, incoherent thought processes, anxiety, and agitation associated with suicidal ideas. The INF therapy was discontinued after two weeks because of these symptoms. Electroencephalogram (EEG) recorded during the mild encephalopathic state demonstrated diffuse θ to slow α-waves in the background without paroxysmal patterns. Magnetic resonance imaging of the brain revealed some small areas of high signal intensity in the white matter which were suggestive of lacunae. Although the neuropsychiatric symptoms subsided two weeks following the cessation of INF, prolonged mental symptoms including lack of volition, interest and labour efficiency persisted for more than 15 months thereafter. The EEG demonstrated slow α-waves in the background mixed with sporadic θ-waves. We speculate that the neuropsychiatric manifestations of encephalopathy may have been induced by INF which crossed the blood-cerebrospinal fluid barriers. Furthermore, we infer that the INF induced and enhanced a latent organic mental syndrome involved in the asymptomatic multiple lacunary infarctions observed in this patient. | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||
| 収録物識別子 | ||||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||||
| 収録物識別子 | 03866092 | |||||||||||||||||||||
| 開始ページ | ||||||||||||||||||||||
| 開始ページ | 41 | |||||||||||||||||||||
| 終了ページ | ||||||||||||||||||||||
| 終了ページ | 46 | |||||||||||||||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 19, 号 1, p. 41-46, 発行日 1994-06 |
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