| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2025-07-09 |
| タイトル |
|
|
タイトル |
Pathophysiological aspects of Gilbert's syndrome and Crigler-Najjar syndrome type II |
|
言語 |
en |
| 作成者 |
Adachi, Yukihiko
Yamashita, Masaki
Kamisako, Toshinori
Murata, Naomi
Yamamoto, Toshio
Aoki, Norihiko
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Gilbert's syndrome, Crigler-Najjar syndrome, bilirubin UDP-glucuronosyltransferase, bilirubin conjugation, biliary bilirubin |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
To determine the common pathophysiological basis in Gilbert's syndrome and Crigler-Najjar syndrome type II, biliary bilirubin moieties and hepatic bilirubin UDP-glucuronosyltransferase activity were measured. The bilirubin UDP-glucuronosyltransferase activity in the liver homogenate decreased to 29% and 11% of the normal (mean) value in Gilbert's syndrome and Crigler-Najjar syndrome type II, respectively. In Gilbert's syndrome and Crigler-Najjar syndrome type II, the mean biliary bilirubin diglucuronide fraction decreased to 55.3% and 9.7% (normal : 76.5%), while the mean bilirubin monoglucuronide fraction increased to 28.0% and 63.1% (normal 9.8%), in Gilbert's syndrome and Crigler-Najjar syndrome type II, respectively. In Crigler-Najjar syndrome type II, a marked increase in bilirubin XIα in bile was also observed. These findings suggest that, stepwise reduction of hepatic bilirubin conjugating capacity is a feature of these syndromes. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
The Kinki University Medical Association |
|
言語 |
en |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03866092 |
| 開始ページ |
|
|
開始ページ |
193 |
| 終了ページ |
|
|
終了ページ |
195 |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 20,
号 3,
p. 193-195,
発行日 1995-09
|
AA0050842X-19950900-0193.pdf (258.3 KB)
