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Expression of inflammatory cytokines in human glomerulonephritis
https://kindai.repo.nii.ac.jp/records/2003149
https://kindai.repo.nii.ac.jp/records/2003149dfe82728-f5ef-45e6-bcf7-ebd280ed8d82
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19950900-0181.pdf (1.1 MB)
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| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-07-09 | |||||||
| タイトル | ||||||||
| タイトル | Expression of inflammatory cytokines in human glomerulonephritis | |||||||
| 言語 | en | |||||||
| 作成者 |
Aya, Naofumi
× Aya, Naofumi
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | interleukin, tumour necrosis factor, glomerulonephritis, monocytes-macrophages | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | We evaluated the expression of inflammatory cytokines in renal tissues obtained from 85 patients with several types of glomerulonephritis. Immunofluorescence studies with specific antibodies to interleukin (IL)-1α, IL-1β, IL-6, IL-8 and tumor necrosis factor (TNF)-α showed intense cytoplasmic staining in the glomeruli and interstitium. Cells positive for these cytokines were found frequently in tissue from patients with lupus nephritis, membranoproliferative glomerulonephritis, and IgA nephritis and, to a lesser extent, in tissue from patients with mesangial proliferative (IgA-negative) glomerulonephritis, Henoch-Schönlein purpura nephritis, and minimal change nephrotic syndrome. Double-immunofluorescent staining revealed that these cytokines were frequently expressed by monocyte-macrophages. In addition, moderate immunofluorescence for TNF-α, and weak staining for IL-1α and IL-6 were occasionally found in resident glomerular cells. Immunoperoxidase-in situ hybridization dual-labeling revealed that IL-1α, IL-6 and TNF-α mRNA signals were present in intraglomerular cells reactive with anti-monocyte-macrophage antibody, which further supported the immunofluorescence findings. In patients with IgA nephritis, the number of IL-1α, IL-6 or TNF-α positive cells infiltrating the glomeruli was significantly correlated with the grade of mesangial hypercellularity. IL-8- and TNF-α-positive intraglomerular cells were significantly correlated with the magnitude of proteinuria. The population of interstitial cells positive for IL-1α, IL-6, IL-8 and TNF-α was associated with the grade of tubulointerstitial changes and proteinuria. There was no correlation between local IL-1α, IL-6 and TNF-α expression in glomeruli or interstitium and serum or urinary levels of the respective cytokines. These findings indicate that several cytokines were simultaneously expressed by infiltrating monocyte-macrophages and, to a lesser extent, by resident glomerular cells, and that IL-1α, IL-6 and TNF-α may be important as promoters of mesangial proliferation in several types of human glomerulonephritis. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 181 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 191 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 20, 号 3, p. 181-191, 発行日 1995-09 |
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