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Alternatives to animal experiments in developmental toxicity studies
https://kindai.repo.nii.ac.jp/records/2003144
https://kindai.repo.nii.ac.jp/records/2003144721191be-9006-4fa2-afc2-29e6cbdd1d8b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19950900-0135.pdf (1.9 MB)
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| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||||
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| 公開日 | 2025-07-09 | |||||||||
| タイトル | ||||||||||
| タイトル | Alternatives to animal experiments in developmental toxicity studies | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Tanimura, Takashi
× Tanimura, Takashi
× Sakamoto, K. Michiko
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| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | developmental toxicology, teratology, embryos, animal testing alternatives, animal welfare, in vitro, mammals, non-mammals, whole embryo culture, organ culture | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Developmental toxicity is the complicated mechanism which should be understood as the mother-fetus complex, and stage specificity is the most important principle. Four checkpoints to examine developmental toxicity exist ; 1) chemical structure, 2) in vitro studies, 3) in vivo mammalian studies, and 4) human surveys. The third checkpoint, in vivo mammalian studies, has been the final and greatest hurdle for chemicals before marketing. However, due to the recent movement of animal welfare, alternatives to animal experiments are emphasized. These alternatives are represented by 3Rs : replacement, reduction and refinement. Accordingly, in developmental toxicity studies, the necessity and usefulness of the second checkpoint, in vitro studies including non-mammalian systems, is increasingly recognized. It should be stressed that these four checkpoints are not one-way but compensate one another. Researches of in vitro studies should aim at the new 3Rs : rapid, reliable and rational. The goals of in vitro studies are divided into two categories : 1) prescreening and 2) mechanistic studies. In the former, the establishment of the battery system based on different developmental mechanisms is urgently awaited. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||
| 言語 | en | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03866092 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 135 | |||||||||
| 終了ページ | ||||||||||
| 終了ページ | 148 | |||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 20, 号 3, p. 135-148, 発行日 1995-09 |
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