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Enhancement of fentanyl, clonidine and serotonin antinociceptive effects by diltiazem in spinal cord of rats
https://kindai.repo.nii.ac.jp/records/2003135
https://kindai.repo.nii.ac.jp/records/200313567359d39-a258-4e0e-897e-7515fed898fd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19951200-0311.pdf (1.5 MB)
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| アイテムタイプ | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-07-09 | |||||||
| タイトル | ||||||||
| タイトル | Enhancement of fentanyl, clonidine and serotonin antinociceptive effects by diltiazem in spinal cord of rats | |||||||
| 言語 | en | |||||||
| 作成者 |
Tsuchiya, Norio
× Tsuchiya, Norio
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | fentanyl, Clonidine, 5-HT, calcium-channel blocker, spinal dorsal horn neuron, nociceptive response, naloxone, yohimbine, methysergide | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Intracellular and extracellular movement of calcium ions regulate neuronal excitability and releases of neurotransmitters in the central nervous system (CNS). The current study was designed to investigate the antinociceptive effects of intrathecal (i.t.) co-administrations of fentanyl (μ-agonists), clonidine (α2-adrenergic agonist) or 5-HT (serotonergic agonist) with diltiazem (a calcium-channel blocker) in rats. Antinociceptive effects were assessed with the tail-flick test. Although higher i.t. doses of fentanyl, clonidine or 5-HT respectively produced a significant antinociceptive effect, lower i.t. doses did not affect the noxious response. When similarly treated, diltiazem alone (100, 200 μg) failed to suppress the nociceptive effects. However, concomitant administrations of antinociceptively inactive doses of fentanyl (1.0 μg), clonidine (2.5 μg) or 5-HT (25 μg) with diltiazem (200 μg) elicited significant suppressions on the thermonociceptive response accordingly. Furthermore, suppressive effects induced by subanalgesic doses of fentanyl, clonidine, or 5-HT, and diltiazem were significantly blocked by naloxone (μ-antagonist), yohimbine (α2-adrenergic antagonist) and methysergide (serotonergic antagonist) respectively. Therefore, it is considered that diltiazem may significantly enhance the antinociceptive effect of each agent. These findings suggest that the calcium channel plays an important role in the antinociceptive effects in the spinal cord of rats. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 311 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 323 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 20, 号 4, p. 311-323, 発行日 1995-12 |
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