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Inhibitory effects of baicalein and wogonin on the growth of B16 melanoma cells
https://kindai.repo.nii.ac.jp/records/2003079
https://kindai.repo.nii.ac.jp/records/200307906c53360-fbf4-455a-88cb-84a9d7421dc3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-19961200-0377.pdf (792.2 KB)
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| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||
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| 公開日 | 2025-07-07 | |||||||
| タイトル | ||||||||
| タイトル | Inhibitory effects of baicalein and wogonin on the growth of B16 melanoma cells | |||||||
| 言語 | en | |||||||
| 作成者 |
Watanabe, Kako
× Watanabe, Kako
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| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | scutellarie radix, baicalein, wogonin, B16 melanoma cells | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | We examined the effects of two flavones, baicalein and wogonin, on the growth and differentiation of mouse B16 melanoma cells in culture. Baicalein and wogonin are plant flavones isolated from the processed root of scutellaria baicalensis Georgi, and have similar chemical structures. Although, these two flavones inhibited the growth of melanoma cells in a dose-dependent manner, the growth inhibitory effect of baicalein was greater than that of wogonin. Both baicalein and wogonin accumulated in the cells in the G0/G1 phase. However, treatment with wogonin led to drastic changes in cell shape, cytoskeleton, and subcellular organelles, whereas no significant morphological changes were observed in cells treated with baicalein. Treatment with wogonin also induced changes in cell function such as melanogenesis, cell detachment, and enzyme activity. These findings indicate that the chemical structure and the antitumor activity of baicalein and wogonin are similar, but their action mechanisms differ. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | The Kinki University Medical Association | |||||||
| 言語 | en | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 03866092 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 377 | |||||||
| 終了ページ | ||||||||
| 終了ページ | 385 | |||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 21, 号 4, p. 377-385, 発行日 1996-12 |
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